Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Phenotypically supervised single cell sequencing parses within-cell-type heterogeneity

ABSTRACT: Phenotypically supervised single cell sequencing parses within-cell-type heterogeneity

PROVIDER: PRJNA666683 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Phenotypically supervised single cell sequencing parses within-cell-type heterogeneity

Project description:We used a phenotypic cell sorting technique to ask whether phenotypically supervised scRNAseq analysis (pheno-scRNAseq) can provide more insight into heterogeneous cell behaviors than unsupervised scRNAseq. Using a simple 3D in vitro breast cancer (BRCA) model, we conducted pheno-scRNAseq on invasive and non-invasive cells and compared the results to phenotype-agnostic scRNAseq analysis. Pheno-scRNAseq identified unique and more selective differentially expressed genes (DEGs) than unsupervised scRNAseq analysis. Functional studies validated the utility of pheno-scRNAseq in understanding within-cell-type functional heterogeneity and revealed that migration phenotypes were coordinated with specific metabolic, proliferation, stress, and immune phenotypes.

2020-10-31 | GSE158844 | GEO

Phenotypically supervised single-cell sequencing parses within-cell-type heterogeneity.

Project description: Not available

| S-EPMC7808958 | biostudies-literature

A phenotypically supervised single-cell analysis protocol to study within-cell-type heterogeneity of cultured mammalian cells.

Project description: Not available

| S-EPMC8165572 | biostudies-literature

Transcriptional Heterogeneity within the Glucocorticoid Response

Project description:Transcriptional Heterogeneity within the Glucocorticoid Response

| PRJNA594939 | ENA

Characterizing phenotypically distinct T cell populations

Project description:Characterizing phenotypically distinct T cell populations

| PRJNA648405 | ENA

Heterogeneity within the PF-EPN-B subgroup

Project description:Heterogeneity within the PF-EPN-B subgroup

| PRJNA481253 | ENA

Deconstructive SCNT reveals heterogeneity within Treg population

Project description:Deconstructive SCNT reveals heterogeneity within Treg population

| PRJNA383046 | ENA

Functional heterogeneity within the developing zebrafish epicardium

Project description:Functional heterogeneity within the developing zebrafish epicardium

| PRJNA498309 | ENA

GNPS - Quantifying Cell Heterogeneity and Subpopulations Using Single Cell Metabolomics

Project description:We combined the Single-probe single cell MS(SCMS) experimental technique with a bioinformatics software package, SinCHet-MS (Single Cell Heterogeneity for Mass Spectrometry), to characterize changes of tumor heterogeneity, quantify cell subpopulations, and prioritize the metabolite biomarkers of each subpopulation.

2023-06-15 | MSV000092178 | GNPS

Single cell RNA-seq defines novel heterogeneity within the pancreatic ductal tree

Project description:Single cell RNA-seq defines novel heterogeneity within the pancreatic ductal tree

| PRJNA668391 | ENA