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Rational biomarker development for the early and minimally invasive monitoring of AML


ABSTRACT: Rational biomarker development for the early and minimally invasive monitoring of AML

PROVIDER: PRJNA667439 | ENA |

REPOSITORIES: ENA

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SRR12773600.fastq.gz Fastqsanger.gz
SRR12773601.fastq.gz Fastqsanger.gz
SRR12773602.fastq.gz Fastqsanger.gz
SRR12773603.fastq.gz Fastqsanger.gz
SRR12773604.fastq.gz Fastqsanger.gz
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Rational biomarker development for the early and minimally invasive monitoring of AML.

Abdelhamed Sherif S   Butler John T JT   Jung Seul S   Chen Ding-Wen DW   Jenkins Gaye G   Gao Lina L   Lim Jeong Y JY   Klco Jeffery M JM   Horton Terzah M TM   Kurre Peter P  

Blood advances 20211101 21


Recurrent disease remains the principal cause for treatment failure in acute myeloid leukemia (AML) across age groups. Reliable biomarkers of AML relapse risk and disease burden have been problematic, as symptoms appear late and current monitoring relies on invasive and cost-ineffective serial bone marrow (BM) surveillance. In this report, we discover a set of unique microRNA (miRNA) that circulates in AML-derived vesicles in the peripheral blood ahead of the general dissemination of leukemic bl  ...[more]

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