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Very low tumor mutation burden identifies inflamed recurrent glioblastomas responsive to cancer immunotherapy

ABSTRACT: Very low tumor mutation burden identifies inflamed recurrent glioblastomas responsive to cancer immunotherapy

PROVIDER: PRJNA668405 | ENA |

REPOSITORIES: ENA

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Very low tumor mutation burden identifies inflamed recurrent glioblastomas responsive to cancer immunotherapy

Project description:Very low tumor mutation burden identifies inflamed recurrent glioblastomas responsive to cancer immunotherapy

| PRJNA668404 | ENA

Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.

Project description: Not available

| S-EPMC7806846 | biostudies-literature

DNA methylation patterns in IDH-wildtype de novo Glioblastomas at first occurrence (primary) and relapsed (recurrent) disease

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RNA-seq of biopsies, crypts and organoids of inflamed and non-inflamed biopsies of ulcerative colitis patients

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2020-10-08 | E-MTAB-7860 | biostudies-arrayexpress

Mutations in IDH1 are associated with DNA hypermethylation in glioblastomas

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Parametric response maps of perfusion MRI may identify recurrent glioblastomas responsive to bevacizumab and irinotecan.

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RNA-seq for inflamed and non-inflamed mucosa in patients with Crohn's disease

Project description:To investigate the gene expression profile of inflamed and non-inflamed mucosa in patients with Crohn's disease. To investigate TCR repertoires in the intestinal mucosa, the expression profile of the TCR repertoire gene was analyzed.

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Genotyping by array of 123 IDH WT glioblastomas

Project description:Glioblastoma (GBM) is the most frequent and most aggressive form of diffuse glioma. The prognosis is very poor, with a median overall survival of 15 months after maximum safe resection and radiochemotherapy.GBM is one of the most genetically unstable cancers. It is characterized by numerous chromosome (chr) copy number alterations (CNA), such as chr 7 gain, chr 9p loss, and chr 10 loss, along with CDKN2A homozygous deletion (chr 9p21) and EGFR amplification (chr 7p11).Chromosome instability (CIN) may be the cause or the consequence of GBM development. In high-grade diffuse gliomas (HGG), CIN may initiate tumorigenesis. To identify recurrent genomic abnormalities in IDH WT glioblastomas, SNP arrays (Illumina 850K CytoSNP) were analyzed for 123 IDH WT GBM cases.

2018-02-27 | E-MTAB-6371 | biostudies-arrayexpress

Array CGH analysis of glioblastomas

Project description:The goal of this study was to investigate genomic aberrations of glioblastoma patients. Keywords: Comparative genomic hybridization We performed array comparative genomic hybridization of 7 glioblastomas using as a reference DNA from healthy donors.

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Mutations in IDH1 are associated with DNA hypermethylation in glioblastomas

Project description:We compared the DNA methylation profiles of 26 glioblastomas harboring mutations in IDH1 with 36 glioblastomas without these mutations on the Illumina HumanMethylation450 BeadChip. Genomic DNA from fresh frozen tumors was bisulfite converted with the Zymo Research EZ DNA Methylation kit, then hybridized to the Illumina HumanMethylation450 Beadchip

2012-06-10 | E-GEOD-32283 | biostudies-arrayexpress

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