Genomics

Dataset Information

109

Mycobacteroides abscessus


ABSTRACT: Sequencing of clinical non-tuberculosis Mycobacteria (NTM) isolates

PROVIDER: PRJNA669041 | ENA |

REPOSITORIES: ENA

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Publications


A 15-year-old patient with cystic fibrosis with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineering and forward genetics. Intravenous phage treatment was well tolerated and associated with objective clinical improvement, including sternal wound closure, improved liver function, and substantia  ...[more]

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