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Adipose tissue adaptations to an 8-week weight loss intervention in younger and older obese men,

ABSTRACT: Adipose tissue adaptations to an 8-week weight loss intervention in younger and older obese men,

PROVIDER: PRJNA670485 | ENA |

REPOSITORIES: ENA

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Skeletal muscle adaptations to an 8-week weight loss intervention in younger and older obese men

Project description:Skeletal muscle adaptations to an 8-week weight loss intervention in younger and older obese men

| PRJNA666688 | ENA

Adipose tissue adaptations to an 8-week weight loss intervention in younger and older obese men,

Project description:Abdominal subcutaneous adipose tissue transcriptomes were analyzed between 11 young and 8 elderly obese men during a lifestyle intervention. Lifestyle intervention: Individuals underwent 8-weeks of calorie-restriction of 20% below their daily energy requirement aerobic combined to two sessions of resistance exercise per weeks.

2021-08-23 | GSE159809 | GEO

Skeletal muscle adaptations to an 8-week weight loss intervention in younger and older obese men

Project description:Vastus lateralis Skeletal muscle transcriptomes were analyzed between 13 young and 12 elderly obese men during a lifestyle intervention. Lifestyle intervention: Individuals underwent 8-weeks of calorie-restriction of 20% below their daily energy requirement aerobic combined to two sessions of resistance exercise per weeks.

2021-08-23 | GSE158850 | GEO

Proteomic assessment of serum biomarkers of longevity in older men

Project description:We utilized a high throughput discovery-based proteomics platform to identify serum peptides and proteins that were associated with the attainment of longevity in a longitudinal study of community-dwelling men age 65 years or older. Baseline serum in 1196 men were analyzed using liquid chromatography-ion mobility-mass spectrometry, and lifespan was determined during ~12 years of follow-up. Men who achieved longevity (>90% expected survival) were compared to those who died earlier.

2020-06-19 | MSV000085611 | MassIVE

Transcription profiling of vastus lateralis muscle from healthy young (21-31 year old) and older (62-77 year old) men

Project description:RNA from vastus lateralis of healthy young (21-31 year old) and older (62-77 year old) men. Signal data normalized to mean intensity of 500 over all probes sets. Analysis done with Affymetrix Microarray Suite 5.0 software.

2007-10-30 | E-GEOD-80 | biostudies-arrayexpress

Metformin Alters Skeletal Muscle Transcriptome Adaptations to Resistance Training in Older Adults

Project description:Metformin Alters Skeletal Muscle Transcriptome Adaptations to Resistance Training in Older Adults

| PRJNA662072 | ENA

Young and old muscle comparison

Project description:RNA was pooled from vastus lateralis biopsies obtained from 8 younger (21-24 yr) and 8 older (66-77 yr)men. Healthy subjects with no neuromuscular disease. Keywords: other

2002-02-01 | GSE17 | GEO

Transcription profiling of human muscle biopises after standard diet and activity regimes

Project description:Muscle biopsies taken from vastus lateralis muscle of 15 men and 15 women after 3 days of standardized diet and activity to examine effects of sex and age; Subjects were either young adults (7 men and 7 women, 20-29 yr old) or older (8 men and 8 women, 65-75 yr old); Affymetrix U133A and U133B arrays were scanned both before (S1) and after (S2) antibody enhancement. This file has U133A S1 data. Effects of age were computed for men and women separately with an alternative method previously and data submitted as GSE362 (men) and GSE674 (women). Experiment Overall Design: Gene expressions profiles were generated for each individual for a total of 30 profiles (15 male, 15 female, 14 younger, 16 older)

2008-06-17 | E-GEOD-9676 | biostudies-arrayexpress

Metformin Alters Skeletal Muscle Transcriptome Adaptations to Resistance Training in Older Adults

Project description:Evidence from clinical trials and observational studies suggests that both progressive resistance training (PRT) and metformin delay a variety of age-related morbidities. Previously, we completed a clinical trial testing the effects of 14 weeks of PRT + metformin (metPRT) compared to PRT with placebo (plaPRT) on muscle hypertrophy in older adults. We found that metformin blunted PRT-induced muscle hypertrophic response. To understand potential mechanisms underlying the inhibitory effect of metformin on PRT, we analyzed the muscle transcriptome in 23 metPRT and 24 plaPRT participants. PRT significantly increased expression of genes involved in extracellular matrix remodeling pathways, and downregulated RNA processing pathways in both groups, however, metformin blunted the number of differentially expressed genes within these pathways compared to plaPRT. Pathway analysis showed that genes unique to metPRT modulated aging-relevant pathways, such as cellular senescence and autophagy. Differentially expressed genes from baseline biopsies in older adults compared to resting muscle from young volunteers were reduced following PRT in plaPRT and were further reduced in metPRT. We suggest that although metformin may blunt pathways induced by PRT to promote muscle hypertrophy, adjunctive metformin during PRT may have beneficial effects on aging-associated pathways in muscle from older adults.

2020-09-08 | GSE157585 | GEO

The footprint of the aging stroma in older breast cancer patients.

Project description:Background: Tumoral masses are not only composed of malignant cells, but also enclose a more or less ample stromal micromilieu, which has been shown to influence the cancer cell behaviour. As aging induces accumulation of senescent cells in the body, this micromilieu is thought to be different in cancers occurring in old patients compared to the younger counterparts. More specifically, senescence-related fibroblastic features, such as the Senescence Associated Secretory Profile (SASP) and the induction of Autophagy, are suspected to stimulate tumor growth and progression. Methods: We compared gene expression profiles in stromal fields of breast carcinomas by performing laser capture microdissection of the cancer-associated stroma from 8 old (≥80 years at diagnosis) and 9 young (< 45 years at diagnosis) triple negative breast cancer patients. Gene expression data were obtained by microarray analysis (Affymetrix). Differential gene expression and Gene Set Enrichment Analysis (GSEA) were performed. Results: Differential gene expression analysis showed higher growth-, dedifferentiation- and migration- promoting gene expression in the stromal samples of older vs younger patients. GSEA confirmed the presence of a SASP, as well as the presence of Autophagy in the stroma of older patients. Conclusion: We provide the first evidence in humans that older age at diagnosis is associated with a different stromal micromilieu in breast cancers. The SASP and the presence of Autophagy appear to be important age-induced stromal features.

2016-11-26 | GSE90521 | GEO

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