Project description:We investigated the effect of an oriental herbal medicine “Taeeumjowuitang” on phenotype characteristics and elucidated anti-obesity mechanism based on RNA-seq transcriptomic profiles in an obesity animal model comparison with green tea extract.
2017-06-12 | GSE71586 | GEO
Project description:Microbiome Analysis in Osteoarthritis Rat Model
Project description:Osteoarthritis (OA) is the most prevalent musculoskeletal disorder and the most common form of arthritis among the elderly. Despite recent basic biology and clinical progress, the understanding and treatment of this and other cartilage-associated diseases are still a challenge. By using an in vivo rat OA model and in vitro human studies we report the improved homeostasis and repairing capacity of two soluble molecules, αKlotho and sTGFBR2, that in combination are able to prevent the progression of OA and promote cartilage regeneration.
2020-01-22 | GSE118559 | GEO
Project description:Gut microbiota of osteoarthritis rat model disturbed by Miya
Project description:Age as the primary rise factor could be play an important role in incidence and development of osteoarthritis. Several studies have confirmed some tissue specific microRNA were associated with development of osteoarthritis. But if age related microRNA or miRNA cluster would be involved in pivotal post-transcriptional gene regulation in osteoarthritis is unclear. In view of this, we have an idea that several age-related miRNAs would be screened from the rat knee cartilage at different development ages by miRNAs Microarray analysis. We used microarrays to detail the global programme of gene expression underlying the rat knee cartilage and identified distinct classes of age-related miRNAs during this process.
Project description:To investigate the functions of ncRNAs in temporomandibular joint osteoarthritis, we established temporomandibular joint osteoarthritis model induced by unilateral anterior crossbite. We then performed gene expression profiling analysis using data obtained from RNA-seq of condylar cartilage at 8 weeks of modeling.
