Project description:Breast cancer ranks top in the incidence among the main sites of female cancer in Japan. The epidemiological study on atomic bomb survivors has suggested that the excess relative risk for breast cancer is higher than any other sites. Little is known, however, about the molecular mechanisms of breast cancer induction by radiation. Therefore, we analyzed here the genome-wide copy number aberration of radiation-induced rat mammary carcinomas using microarray-based comparative genomic hybridization (array-CGH). Mammary carcinomas were induced by 2 Gy gamma irradiation of Sprague-Dawley (SD) rats at 3 or 7 weeks of age. We examined 14 mammary carcinomas induced by gamma-irradiation (2 Gy) and found 26 aberrations including trisomies of chromosomes 4 and 10 in 3 and 1 carcinomas, respectively, and deletion of chromosomes 3q35q36 and 5q32 (Cdkn2a and Cdkn2b region) in 2 and 2 carcinomas, respectively. On the other hand, only one aberration (amplification of chromosome 10q31) was observed in four spontaneous mammary carcinomas. These results suggest that the trisomy of chromosome 4 and deletion of chromosomes 3q35q36 and 5q32 were associated with radiation exposure. We performed aCGH on mammary carcinoma in Sprague-Dawley rat to identify radiation-specific DNA copy number aberration compared with spontaneous mammary carcinoma.

2010-08-08 | E-GEOD-16128 | biostudies-arrayexpress

Radiation-specific DNA copy number aberration in rat mammary carcinoma.

2010-08-09 | GSE16128 | GEO

DNA copy number alterations in neutron- or gamma-ray-induced rat mammary carcinomas

Project description:To investigate DNA copy number changes in rat mammary carcinomas induced by neutron or gamma-ray irradiation.

2020-10-29 | GSE160418 | GEO

Genomic DNA copy number alterations of radiation-induced lung adenocarcinomas in mice

Project description:To investigate DNA copy number changes in mouse lung cancers induced by ionizing radiation.

2023-04-26 | GSE174131 | GEO

Multi-region copy-number analysis

Project description:Intra-tumour heterogeneity (ITH) foster tumour adaptation and hamper the efficiency of personalised medicine approaches. We investigated the extent of ITH within individual clear cell renal cell carcinomas (ccRCC) by multi-region sampling and copy number analysis. We analyzed 63 tumour regions and 8 normal samples from eight clear cell renal cell carcinomas using Affymetrix SNP6 arrays.

2013-06-04 | GSE47077 | GEO

Genomic DNA copy number alterations of mouse B-cell lymphomas induced by ionizing radiation

Project description:To investigate DNA copy number changes in mouse B-cell lymphoma induced by ionizing radiation.

2022-12-12 | GSE192455 | GEO

Multi-region copy-number analysis

2013-06-04 | E-GEOD-47077 | biostudies-arrayexpress