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Whole transcriptome analysis of the antidepressant baicalin in chronic unpredictable mild stress mice

ABSTRACT: Whole transcriptome analysis of the antidepressant baicalin in chronic unpredictable mild stress mice

PROVIDER: PRJNA673702 | ENA |

REPOSITORIES: ENA

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Whole transcriptome analysis of the antidepressant baicalin in chronic unpredictable mild stress mice

Project description:We identified 371 differentially genes including 216 up-regulated and 155 down-regulated genes by calculating the gene FPKM in each sample. The clustering analysis showed that differentially genes were separated into two distinguishing branches. Gene ontology analysis suggested that differentially genes mainly involved regulation of transcription (DNA-templated), transcription (DNA-templated), and protein phosphorylation in biological process, DNA binding, ATP binding and transferase activity in molecular function, and synapse, postsynaptic density, postsynaptic membrane in cellular component. Among these results indicated that the effect of baicalin may involve synapse function and ATP regulation.

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Project description:Baicalin is the main flavonoid component extracted from Scutellaria root. It has multiple potent biological activities, including estrogen-like activity. In our study, we investigated the function of baicalin on mammary stem cell proliferation and mammary development. Our results demonstrated that baicalin significantly accelerates mammary gland development at puberty and during pregnancy; In vitro, baicalin significantly promotes colony formation ability of mammary basal epithelial cells in a three-dimensional (3D) culture system; In vivo, baicalin improved mammary regeneration efficiency in mouse xenograft model. But the mechanism was unknown. Therefore, transcriptome analysis of basal and luminal cells treatment with baicalin was performed.

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Project description:We performed high-throughput profiling of gene expression in rat hippocampus in response to chronic unpredictable mild stress (CUMS) and albiflorin treatment. Total 415 differentially expressed genes (DEGs) were identified in rat hippocampus in response to albiflorin treatment compared with CUMS rats treated with saline (CUMS-Sal). We conducted the integrated metabolomics and transcriptomics analysis and found the correction of 16 biochemical pathways by albiflorin such as sphingolipids, phospholipids, tryptophan metabolism, fatty acid oxidation, and purine and pyrimidine metabolism. Our study provided deep insights into the understanding of the molecular mechanisms underlying the rapid antidepressant actions of albiflorin.

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