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Estrogen-related receptor γ agonist DY131 ameliorates lipopolysaccharide-induced acute liver injury

ABSTRACT: Estrogen-related receptor γ agonist DY131 ameliorates lipopolysaccharide-induced acute liver injury

PROVIDER: PRJNA674766 | ENA |

REPOSITORIES: ENA

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Project description:DY131 is a pharmacological agonist of the orphan receptor estrogen-related receptor (ERR) γ which plays a crucial role in regulating energy generation, oxidative metabolism, cell apoptosis, inflammatory responses, etc. However, its role in acute liver injury is unknown. In the study, we evaluated the effect of DY131 on lipopolysaccharide (LPS)-induced liver injury. Transcriptomics analysis revealed that the dysregulated pathways associated with inflammation and metabolism were significantly reversed by DY131 in LPS-treated mice, providing more evidence in favor of the protective effect of DY131 against LPS-induced liver injury.

2020-11-06 | GSE160880 | GEO

Project description: Not available

| S-EPMC8104008 | biostudies-literature

RNA Sequencing in LXR agonist fed Atp7b-/- mice (Wilson disease)

Project description:The goal of the study was find the gene expression of diverse signaling pathways altered in Atp7b-/- mice (murine WD) liver as compared to control mice and how LXR agonist treatment will improve/ameliorate WD phenotype in Atp7b-/- mice. Activation of LXR/RXR using synthetic LXR agonist ameliorates liver inflammation and fibrosis in murine WD by changing gene expression.

2022-10-26 | GSE174015 | GEO

Therapeutic Targeting of Ovarian Cancer Stem Cells Using Estrogen Receptor Beta Agonist

Project description:Therapeutic Targeting of Ovarian Cancer Stem Cells Using Estrogen Receptor Beta Agonist

| PRJNA809731 | ENA

RNA sequencing of HepG2 cells treated with estradiol or estrogen receptor agonist

Project description:RNA sequencing of HepG2 cells treated with estradiol or estrogen receptor agonist

| PRJNA449680 | ENA

Therapeutic Targeting of Ovarian Cancer Stem Cells Using Estrogen Receptor Beta Agonist

Project description:We examined the transcriptional changes altered by ERβ agonist LY500307 treatment in ovarian cancer stem cells (OCSCs) by performing global transcriptome analysis. SKOV3-ALDH+ OCSCs were treated with vehicle or LY500307 (5 µM) for 24 h and the RNA was isolated and utilized for RNA-seq analysis. Our results demonstrated that the top pathways altered by LY500307 were related to cell cycle and apoptosis. Functional enrichment using GSEA analysis showed that LY500307-regulated genes showed positive enrichment in the p53 pathway, oxidative phosphorylation, apoptosis and estrogen late response genes, and negative correlation with E2F targets, G2/M checkpoint and mitotic spindle.

2022-07-13 | GSE197320 | GEO

AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis

Project description:Nonalcoholic steatohepatitis (NASH) and associated liver fibrosis have limited therapy options. We report a novel adiponectin-based dual agonist for adiponectin receptors 1 and 2 with a longer half-life, and show that it ameliorates NASH and liver fibrosis in mouse models.

2020-10-03 | GSE158951 | GEO

Transcription profiling of rat peripheral blood leukocytes treated with the estrogen receptor agonists estradiol, PPT and DPN to investigates the functional roles of estrogen receptor alpha and beta

Project description:This experiment investigates the functional roles of estrogen receptor alpha and beta in peripheral blood leukocytes by using selective estrogen receptor agonists. The agonists that are used are estradiol (E2), the selective ER-alpha agonist PPT (4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol) and the selective ER-beta agonist DPN (2,3-bis(4-hydroxyphenyl)-propionitrile).

2007-05-30 | E-TABM-269 | biostudies-arrayexpress

RNA sequencing of HepG2 cells treated with estradiol or estrogen receptor agonist

Project description:We report differential expressed genes in HepG2 cells treated with control, E2, or an ER agonist

2018-12-10 | GSE112983 | GEO

SIRPa agonist antibody treatment ameliorates experimental arthritis and colitis [sequencing]

Project description:The innate immune system is finely tuned to enable rapid response to pathogenic stimuli but keep quiescent during tissue homeostasis.Balance of activating and inhibitory signaling sets a threshold for immune activation. Signal regulatory protein (SIRPa) is an immune inhibitory receptor expressed by myeloid cells and interacts with CD47 to inhibit immune cell phagocytosis, migration, and activation. Despite the progress of SIRPa and CD47 antagonist antibodies to promote anti-cancer immunity, it is not yet known whether therapeutic SIRPa receptor agonism could restrain excessive autoimmune inflammation in the context of autoimmunity. Here, we reported that increased neutrophil- and monocyte-associated genes including SIRPA in inflamed tissues biopsies of rheumatoid arthritis and inflammatory bowel diseases, and elevated SIRPA in colonic biopsies is associated with treatment refractory ulcerative colitis patients. We next identified a novel agonistic anti-SIRPa antibody that exhibited potent anti-inflammatory effects in reducing neutrophil and monocytes chemotaxis and tissue infiltration. In preclinical models of arthritis and colitis, anti-SIRPa agonistic antibody ameliorates autoimmune joint inflammation and inflammatory colitis through reducing neutrophils and monocytes in tissues. Our work provides a proof-of-concept for SIRPa receptor agonism for suppressing excessive innate immune activation and autoimmune inflammatory therapeutic treatment

2023-08-24 | GSE235400 | GEO

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