Project description:LM2-4175 cell line was originally selected from MDA-MB-231,but has more aggressive characteristics in invasion, migration and metastasis. In addition, LM2 cell line specifically metastasizes to lung. To understand the melecular mechanisms of lung metastasis in breast cancer,we analyzed the RNA-seq data of MDA-MB-231 and LM2-4175 cell lines.

2019-07-31 | GSE124380 | GEO

Analysis of HNRNPC Interactome in MDA-MB231 parental and LM2 cells

Project description:To define and compare the interactomes of the RNA binding protein HNRNPC in poorly vs. efficiently metastatic breast adenocarcinoma cells, we carried out immunoprecipitation of endogenous HNRNPC from parental MDA-MB231 cells vs. its highly metastatic isogenic derivate, the MDA-MB231-LM2 cells. We used a non-specific MOUSE IgG IP from each line as control. Each IP was performed in triplicate, and analysed by LC-MS/MS, on a Thermo Q-Exactive-plus instrument.

2023-02-19 | PXD029560 | Pride

Differential transcript stability measurements in MDA-MB-231 vs. MDA-LM2 cells

Project description:We performed whole-genome stability measurements for MDA-MB-231 and its highly metastatic derivative MDA-LM2. Our goal was to identify post-transcriptonal regulons that are deregulated en route to higher metastatic capacity.

2014-07-24 | GSE49608 | GEO

SRSF1 HITS-CLIP in MDA-LM2

Project description:To identify SRSF1 binding sites on RNAs, we performed HITS-CLIP of endogenous SRSF1 in MDA-LM2 cells

2019-12-26 | GSE131745 | GEO

RNA sequencing of SNRPB2 knockdown in MDA-LM2 cells

Project description:We used RNA sequencing to compare SNRPB2 knockdown cells to mock-transfected controls.

2021-03-30 | GSE160952 | GEO

RNA sequencing of SNRPA1 knockdown in MDA-LM2 cells

Project description:We used RNA sequencing to compare SNRPA1 knockdown cells to mock-transfected controls respectively.

2021-03-30 | GSE160950 | GEO