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Chromatin accessibility changes in experimentally-induced basal to squamous cell carcinoma transition (BST)

ABSTRACT: Chromatin accessibility changes in experimentally-induced basal to squamous cell carcinoma transition (BST)

PROVIDER: PRJNA675105 | ENA |

REPOSITORIES: ENA

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Chromatin accessibility changes in experimentally-induced basal to squamous cell carcinoma transition (BST)

Project description:Basal cell carcinoma may undergo BST spontaneously or upon Hedgehog targeting therapy. We identified that modulation of Ras/MAPK or TGFb signaling drive BST. Here, we induce Ras/MAPK and/or abrogate TGFb signaling to induce BST. Alternatively we drive c-FOS to induce BST. In these various experimentally-induced model of BST, we analyze chromatin accessibility profiles upon Ras/MAPK activation and/or TGFb signaling abrogation. We also analyze chromatin accessibility profiles upon c-FOS activation.

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