Project description:To investigate the effect of PBK inhibitor OTS514 on gene expression, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to suppress the cell proliferation of human OSCC cell lines. The OSCC cells were treated with OTS514 (20 nmol/L) for 24 h in vitro.

2022-04-30 | GSE197263 | GEO

Gene expression signatures in EGFR-deleted oral squamous cell carcinoma (OSCC) cell lines

Project description:To investigate the effect of EGFR disruption on gene expression, we generated EGFR-knockout (EGFR-KO) cell clones using CRISPR/Cas9 system with OSCC cell lines HSC-2 and HSC-3 cells. The OSCC cells were incubated for 48 h in vitro.

2023-05-01 | GSE222629 | GEO

Gene expression signatures for plumbagin (PL) treatment in OSCC cell lines

Project description:To investigate the effect of PL on gene expression, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to suppress the cell proliferation of OSCC cell lines. SAS and HSC-3 cells were treated with PL (5 μmol/L) for 4 h in vitro.

2021-12-24 | GSE188168 | GEO

Aberrant lncRNA expression profiles in OSCC plasma

Project description:Carcinogenesis is a genetic process in which molecular changes occur earlier than histomorphological changes. The key to early detection of oral squamous cell carcinoma (OSCC) is to identify genetic alterations. However, aberrant lncRNA expression profiles in OSCC plasma is still largely unknown. Using an lncRNA microarray, we analyzed the aberrant lncRNA expression profiles in OSCC plasma compared with paired healthy volunteer plasma. Our data revealed 7473 differentially expressed (Fold Change >= 2.0, P-value <= 0.05) lncRNAs, among which 3972 lncRNAs were significantly up-regulated and 3501 lncRNAs were down-regulated in OSCC compared with paired healthy volunteer plasma.

2021-01-22 | GSE97251 | GEO

Gene expression profiling of oral squamous cell carcinoma (OSCC)

Project description:OSCC is associated with substantial mortality and morbidity. To identify potential biomarkers for the early detection of invasive OSCC, we compared the gene expressions of OSCC, oral dysplasia, and normal oral tissue from patients without oral cancer or preneoplastic oral lesions (controls). Results provided models of gene expression to distinguish OSCC from controls.

2011-07-22 | GSE30784 | GEO

microRNA expression profiles in myocardium of diet-induced obesity rat

Project description:Diet induced obesity in rat was associated with myocardial dysfunction, hypertension and fibrosis. This study aimed to explore microRNA expression profiles in diet obesity-induced rat myocardium. Wistar rats were feed normal chow or high-fat diet for 20 weeks. After that, cardiac function was evaluated by echocardiography. Left ventricular myocardium was harvest to assess the extent of hypertension and fibrosis, meanwile, the left ventricular microRNA expression was analyzed using Agilent Rat miRNA microarray. Significant cardiac dysfunction, hypertension and fibrosis were found in diet-induced obesity rats as compared with normal diet rats. rno-miR-141-3p and rno-miR-144-3p were also significantly increased in myocardium of diet-induced obesity rat. These findings suggest that specific miRNA differences may contribute to the alteration in cardiac function, hypertension and fibrosis which responses to diet-induced obesity.

2020-01-07 | GSE143168 | GEO

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