Genomics

Dataset Information

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CPD-seq map of UV damage formation in isolated human genomic DNA


ABSTRACT: CPD-seq map of UV damage formation in isolated human genomic DNA

PROVIDER: PRJNA680700 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR13132461.fastq.gz Fastqsanger.gz
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Publications


Somatic mutations in DNA-binding sites for CCCTC-binding factor (CTCF) are significantly elevated in many cancers. Prior analysis has suggested that elevated mutation rates at CTCF-binding sites in skin cancers are a consequence of the CTCF-cohesin complex inhibiting repair of UV damage. Here, we show that CTCF binding modulates the formation of UV damage to induce mutation hot spots. Analysis of genome-wide CPD-seq data in UV-irradiated human cells indicates that formation of UV-induced cyclobu  ...[more]

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