Project description:Study of loss of ZEB2 in breast cancer cells in vitro and in vivo: gene expression and phenotypic switch to more benign behavior of the cancer cells. Morphological, functional and gene microarray analysis following ZEB2 knockdown in MDAMB231 cells reveals gain of epithelial differentiation, reduction of migration, invasion and metastatic capability. The measurement of ZEB2 transcriptional activity in tumor cells efficiently predicts the probability of breast cancer patient survival. Global gene expression profiles were measured using Affymetrix U133 plus2 microarrays in MDAMB231 cells (control and ZEB2 shRNA and siRNA knockdown cells on plastic)

2016-03-15 | E-GEOD-27966 | biostudies-arrayexpress

Transcriptome analysis of SAP30BP knockdown cells

Project description:Examination of transcriptome of SAP30BP knockdown cells by Ribosomal RNA depleted RNA-Seq

2023-12-03 | GSE220906 | GEO

Transcriptome analysis of SFP45 knockdown cells

Project description:Examination of transcriptome of SPF45 knockdown cells by Ribosomal RNA depleted RNA-Seq

2020-07-30 | GSE135128 | GEO

Effect of G0s2 and Rgs16 knockdown on hepatic transcriptome

Project description:We identified 2 leading gene candidates (G0s2 and Rgs16) in response to circadian, diet and genetic manipulations by a large-scale transcriptome analysis. To examine the impact of G0s2 and Rgs16 on liver functions, we carried out adenovirus-mediated liver-specific knockdown of both genes and performed RNA-seq analysis.

2021-08-03 | GSE181262 | GEO

Nucleosome Positioning and Histone Modifications Define Relationships between Regulatory Elements and Nearby Gene Expression in Breast Epithelial Cells

Project description:We report the application of FAIRE seq and ChIP seq in breast cancer cell line, MDAMB231. Examination of FAIRE and ChIP assay in MDAMB231

2013-12-31 | E-GEOD-49651 | biostudies-arrayexpress

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