Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Integrative analysis of lncRNA and mRNA and profiles in postoperative delirium patients

ABSTRACT: Integrative analysis of lncRNA and mRNA and profiles in postoperative delirium patients

PROVIDER: PRJNA688295 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Integrative analysis of lncRNA and mRNA and profiles in postoperative delirium patients

Project description:Delirium is a common serious complication that often occurs after major surgery. However, there is little known about the function of long non-coding RNAs (lncRNAs) in postoperative delirium (POD). The goals of this study were to explore the expression profiles and functional networks of lncRNAs and mRNAs in patients of POD.

2021-06-09 | GSE163943 | GEO

Integrative Analysis of lncRNA and mRNA and Profiles in Postoperative Delirium Patients.

Project description: Not available

| S-EPMC8171121 | biostudies-literature

Integrative analysis of mRNA and lncRNA profiles identified pathogenetic lncRNAs in esophageal squamous cell carcinoma

Project description:Systems biology approaches can help understand pathogenesis of complex human diseases like cancers for identification of potential new therapeutic targets. Here in this study, we performed genome-wide screening for mRNA and lncRNA profiles in esophageal cancer to identify the novel cancer-related mRNA and lncRNA in esophageal squamous cell carcinoma (ESCC). We identified 3000 up-regulated/2517 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. At last, mRNA and lncRNA co-expression network were built and highly-connected networks were identified, which may provide a mechanism of mRNA expression regulation by lncRNA. To our knowledge, this is the first study to explore the co-expression networks and the lncRNA-mRNA networks could be therapeutic targets for ESCC treatments.

2019-02-23 | GSE111011 | GEO

Integrative analysis of mRNA and lncRNA profiles identified pathogenetic lncRNAs in esophageal squamous cell carcinoma

Project description:Integrative analysis of mRNA and lncRNA profiles identified pathogenetic lncRNAs in esophageal squamous cell carcinoma

| PRJNA435587 | ENA

CRC lncRNA/mRNA expression

Project description:CRC lncRNA/mRNA expression

| PRJNA555486 | ENA

Identification and functional analysis of a potential key lncRNA in aged mice with postoperative cognitive dysfunction

Project description:Postoperative cognitive decline (POCD) is emerging as a significant complication of surgery in elderly patients. However, the molecular mechanisms of POCD are elusive. Here we applied microarray analyses to identify long non-coding RNA (lncRNA) and mRNA expression profiles in hippocampal tissues from a mouse model of POCD and control mice. A total of 869 lncRNAs and 690 mRNAs were differentially expressed between POCD and control mice. Subsequently, six dysregulated lncRNAs and six mRNAs were confirmed via quantitative real-time polymerase chain reaction (qRT-PCR) in 8 paired samples. Then, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to probe the vital functions of dysregulated genes.

2019-08-20 | GSE113738 | GEO

Plasma lncRNA and mRNA profiles in patients with NSCLC: Pre-operation vs. post-operation

Project description:Circulating transcriptional landscapes between pre-operation and post-operation plasma samples were compared using the Arraystar Human LncRNA Microarray V4 with probes for profiling of 40173 human lncRNAs and 20730mRNAs. Goal was to investigate the impact of tumor removal on circulating lncRNA and mRNA expression levels.

2018-12-31 | GSE99870 | GEO

lncRNA and mRNA profiles show difference in Tetralogy of Fallot

Project description:In this study,compared with normal group, there were 94 differentially expressed lncRNAs and 83 mRNA transcripts in TOF (P<0.05). Correlation analysis between lncRNA and mRNA further showed that differentially expressed lncRNA can be linked to mRNAs, suggesting the regulator role of lncRNA in mRNA expression

2022-11-23 | GSE184905 | GEO

lncRNA and mRNA expression profiles during osteoclastogenesis

Project description:Total RNA were extracted from osteoclasts differentiated from RAW264.7 cells at different stages: Monocytes (0h), Pre-osteoclasts (24h), Mature osteoclasts (72h) and activated osteoclasts (96h). LncRNA and mRNA expression profiles were decided by microarray. RAW264.7 cells were cultured with RANKL (100ng/ml) and M-CSF (50ng/ml) for 0h, 24h, 72h and 96h. TRAP stain, FAK stain, pit formation assay, fusion assay and q-PCR were performed to validate the in vitro model.

2015-08-28 | E-GEOD-72478 | biostudies-arrayexpress

m6A-mRNA&lncRNA Epitranscriptomic Microarray

Project description:m6A-mRNA&lncRNA Epitranscriptomic Microarray

| PRJNA774778 | ENA