Project description:This SuperSeries is composed of the following subset Series: GSE39525: 5 Day Oral Study of A-998679 in Male Sprague Dawley Rats (liver) GSE39850: 5 Day Oral Study of A-998679 in Male Sprague Dawley Rats (Jejunum) Refer to individual Series

2012-08-03 | E-GEOD-39875 | biostudies-arrayexpress

Sprague-Dawley rats

Project description:16S rRNA gene sequencing analysis of Sprague-Dawley rat

| PRJNA732723 | ENA

microRNA profiling of Sprague Dawley organs

Project description:We performed deep sequencing of the miRNAs present in ~20 toxicologically relevant tissues in Sprague Dawley rats and used three independent analysis of the data to determine which miRNAs are tissue specific and tissue enriched. We performed deep sequencing of miRNAs in 21 organs from 5 male Sprague Dawley rats and 23 organs from 5 female Sprague Dawley rats.

2016-09-01 | E-GEOD-78031 | biostudies-arrayexpress

Rattus norvegicus strain:Sprague-Dawley rats

Project description:Rattus norvegicus strain:Sprague-Dawley rats Raw sequence reads

| PRJNA687124 | ENA

Rattus norvegicus strain:Sprague-Dawley

Project description:Transcriptome of Sprague-Dawley rats

| PRJNA318311 | ENA

mRNA array in liver tissue samples of Sprague-Dawley rats

Project description:Non-alcoholic fatty liver disease (NAFLD) has increased over the last decades and may evolve into hepatocellular carcinoma (HCC). As HCC is challenging to treat, knowledge on the modifia-ble risk factors for NAFLD/HCC, (e.g. hypercaloric diets rich in fructose) is essential. We used a model of diethyl nitrosamine-induced hepatocarcinogenesis to investigate the liver cancer-promoting effects of a diet supplemented with 10% liquid fructose, administered to male and female rats for 11 months. A subset of the fructose-supplemented rats received resveratrol in the last 4 months of treatment. We observed metabolic abnormalities mainly in the female fructose-supplemented rats (increases in weight, adiposity, and plasma glucose and triglycerides, as well as liver triglycerides and a reduced insulin sensitivity index), which were partially reversed by resveratrol. The livers of fructose-supplemented rats showed no de visu or histological evi-dence of liver tumorigenesis. Targeted analysis of 84 cancer-related genes in the female liver samples revealed expression changes associated with cancer-related pathways, but individual genes indicated that some changes increased the risk of hepatocarcinogenesis (Sfrp2, Ccl5, Socs3, and Gstp1), while others exerted a protective/preventive effect (Bcl2 and Cdh1). In conclusion, our data do not clearly demonstrate that chronic fructose supplementation promotes HCC development in rats.

2020-12-30 | GSE163966 | GEO

5 Day Oral Study of A-998679 in Male Sprague Dawley Rats (liver)

Project description:Male Sprague-Dawley rats [Crl:CD®(SD)IGS BR], weighing ~250 g at study initiation were obtained from Charles River Laboratories, Inc. (Wilmington, MA). Rats were housed singly in ventilated, stainless steel, wire-bottom hanging cages and fed non-certified Rodent Chow (Harlan Labs, Madison, WI) and water ad libitum and acclimated for at least 5 days after arrival. Rats were randomly assigned to various treatment groups (3 rats/group) and were dosed once daily by oral gavage with vehicle (0.2% hydroxypropylmethylcellulose at a dose volume of 10 ml/kg) or with 30, 100, or 200 mg/kg of A-998679. All rats were fasted overnight after their last dose, weighed and sacrificed under isoflurane anesthesia. Liver and small intestine (jejunum) were flash frozen in liquid nitrogen and stored at −80°C until processing for gene expression profiling on the Affymetrix platform.

2012-07-24 | GSE39525 | GEO

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