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Transcriptome analysis of KM-H2 cells with different Rhodamin 123 eflux capacity

ABSTRACT: Transcriptome analysis of KM-H2 cells with different Rhodamin 123 eflux capacity

PROVIDER: PRJNA689846 | ENA |

REPOSITORIES: ENA

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Transcriptome analysis of KM-H2 cells with different Rhodamin 123 eflux capacity

Project description:Rhodamin 123 is a dye which can be used to detect the activity of ABC transporters. We observed that after staining of KM-H2 Hodgkin lymphoma cells with Rhodamin 123, part of the cells rapidly eliminated the dye, while another part of the cells retained the dye for a longer time. We compared the transcriptome of KM-H2 Hodgkin lymphoma cells with high Rhodamin 123 efflux capacity and KM-H2 cells with low Rhodamin 123 efflux capacity.

2021-01-06 | GSE164318 | GEO

Expression changes induced by PTPN1 knockdown in KM-H2 cells

Project description:Gene expression data for shRNA PTPN1 knockdown vs. Non-silencing in the classical Hodgkin lymphoma-derived cell line KM-H2

2014-01-17 | GSE54157 | GEO

Gene expression profile of KM-H2 cells conditional expressing PU.1

Project description:PU.1 is an Ets family transcription factor that is essential for the differentiation of both myeloid and lymphoid cells. PU.1 is down-regulated in classical Hodgkin lymphoma cells via methylation of the PU.1 promoter. To evaluate whether down-regulation of PU.1 is essential for the growth of cHL cells, we generated KM-H2 derived cell lines conditionally express PU.1 by tet-off system (designated KM-H2tetPU.1). Conditonally expressed PU.1 by tetracycline removal induced complete growth arrest and apoptosis in KM-H2 cells. To elucidate the mechanisms underlying cell cycle arrest and apoptosis induced by PU.1, we compared gene expression profiles of KM-H2tetPU.1 cells 0, 1 and 3 days after PU.1 induction, by DNA microarray.

2012-11-22 | GSE42440 | GEO

Effect of lestaurtinib on KM-H2 HRS cell line

Project description:Effect of the tyrosine kinase inhibitor (TKI) lestaurtinib on Hodgkin and Reed/Sternberg (HRS) cell line KM-H2 compared to the solvent treated control.

2012-02-21 | E-MEXP-3565 | biostudies-arrayexpress

Gene expression profile of KM-H2 cells conditional expressing PU.1

2012-11-22 | E-GEOD-42440 | biostudies-arrayexpress

Expression changes induced by PTPN1 knockdown in KM-H2 cells

Project description:Gene expression data for shRNA PTPN1 knockdown vs. Non-silencing in the classical Hodgkin lymphoma-derived cell line KM-H2 A total of 4 samples were analyzed (2 Knockdown vs. 2 Non-silencing). The 2 knockdown and 2 non-silencing samples are technical replicates of each other.

2014-01-17 | E-GEOD-54157 | biostudies-arrayexpress

Expression data from H2-producing Rhodobacter sphaeroides cultures fed different organic substrates

2011-08-22 | GSE29811 | GEO

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Project description:123

| PRJEB35310 | ENA

Expression data from H2-producing Rhodobacter sphaeroides cultures fed different organic substrates

Project description:Rhodobacter sphaeroides produces hydrogen gas (H2) via its nitrogenase enzyme during photoheterotrophic growth under nitrogen-limited conditions. We find that cells produce different amounts of H2 and show different growth rates, depending on the organic substrate provided (lactate, succinate, glucose, xylose, or glycerol). We used global transcript analyses to determine what genes are involved in the onset of H2 production, and those that lead to different H2 production capacities in cells fed different organic substrates. Growth and real-time H2 production were followed for photoheterotrophically grown Rhodobacter sphaeroides cultures (19 mL test tube cultures) fed one of five different organic substrates (lactate, succinate, glucose, xylose, or glycerol) and provided glutamate as the sole nitrogen source. Cells were harvested for RNA extraction during early post-exponential growth, at points near the maximum H2 production rates of the cultures. Non-H2-producing cells (500 mL cultures) fed succinate and provided NH4+ as nitrogen source were also harvested for RNA extraction as reference samples. At least two samples for every given set of conditions were analyzed.

2011-08-21 | E-GEOD-29811 | biostudies-arrayexpress

Sphingomonas sp. H2 strain:H2 | isolate:H2

Project description:Sphingomonas sp. H2 strain:H2 | isolate:H2 Genome sequencing and assembly

| PRJNA732547 | ENA