Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CSER: Genomic Sequencing to Aid Diagnosis in Pediatric and Prenatal Practice: Examining Clinical Utility, Ethical Implications, Payer Coverage, and Data Integration in a Diverse Population

ABSTRACT: CSER: Genomic Sequencing to Aid Diagnosis in Pediatric and Prenatal Practice: Examining Clinical Utility, Ethical Implications, Payer Coverage, and Data Integration in a Diverse Population

PROVIDER: PRJNA689886 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

CSER: Clinical Sequencing in Cancer: Clinical, Ethical, and Technological Studies

Project description:CSER: Clinical Sequencing in Cancer: Clinical, Ethical, and Technological Studies

| PRJNA297609 | ENA

CSER: Clinical Sequencing in Cancer: Clinical, Ethical, and Technological Studies

Project description:<p>The Clinical Sequencing Exploratory Research (CSER) program supports multi-disciplinary projects that bring together clinicians, bioinformaticians, and ethicists to research the challenges of utilizing genomic sequence data in the clinic in the routine practice of medicine. The challenges are many and not disease-specific. Important aims of the research include: development of technical specifications and standards for sequencing in a clinical setting, investigation of methods to transmit genome-scale data to physicians in a fashion and timescale that fits the normal clinical workflow, exploration of regulatory requirements for applying genomic sequence data to patient care, study of physician and patient preferences regarding presentation of genomic information, and study of the ethical implications of returning unanticipated findings. More information about CSER and the investigators and institutions who comprise the CSER consortium can be found at <a href="http://www.genome.gov/27546194" target="_blank">http://www.genome.gov/27546194</a>.</p> <p>The NEXT (New Exome Technology) Medicine Study utilizes a randomized controlled trial (RCT) structure to compare usual care (UC) practice in Medical Genetics Clinics with the introduction of a powerful research tool of whole exome sequencing plus UC practices for Colorectal Cancer and Polyposis (CRCP) in adults. In doing so, the study aims to explore the practical, economic, and ethical implications of identifying and returning incidental findings ("extra" whole exome genetic risk results not associated with CRCP that includes pharmacogenetic variants) to patients. The study will also attempt to identify novel causal genes for CRCP by studying relatives of selected research subjects.</p>

| phs000999 | dbGaP

NGS zwc practice

Project description:to practice use ebi

| PRJEB28063 | ENA

Genomic Counter-Stress Changes Induced by Mind-Body Practice

Project description:Mind-body practices that elicit the relaxation response (RR) have been used worldwide for millennia to prevent and treat disease. The RR is believed to be the counterpart to stress response and is characterized by decreased oxygen consumption, increased exhaled nitric oxide, and reduced psychological distress. Individuals experiencing chronic psychological stress have the opposite pattern of physiology and a characteristic transcriptional profile. We hypothesized that consistent, long-term practice of RR techniques results in characteristic changes in gene expression. We tested this hypothesis by assessing the transcriptional profile of whole blood in healthy, long-term practitioners of daily RR practice (group M) in comparison to healthy controls (group N1). The signature obtained has been validated on new subject data. Experiment Overall Design: In the study, the gene expression profiling was performed on individuals with a long-term RR practice (group M; n=19) or those with no prior RR experience; novice (group N1; n=19). Group N1 novices, furthermore, underwent 8-weeks of RR training (Group N2; n=20) for the prospective analysis.As a validation of results , we developed an independent validation sets that includes gene expression profiling on 4 N1, 4 N2 and 6 M subjects.

2008-10-21 | E-GEOD-10041 | biostudies-arrayexpress

Homo sapiens

Project description:CSER: Clinical Sequencing in Cancer: Clinical, Ethical, and Technological Studies

| PRJNA297610 | ENA

Examining access to care in clinical genomic research and medicine: Experiences from the CSER Consortium.

Project description: Not available

| S-EPMC8634302 | biostudies-literature

Genomic Counter-Stress Changes Induced by Mind-Body Practice

2008-07-05 | GSE10041 | GEO

CSER: Evaluating utility and improving implementation of genomic sequencing for pediatric cancer patients in the diverse population and healthcare settings of Texas: The KidsCanSeq Study

Project description:CSER: Evaluating utility and improving implementation of genomic sequencing for pediatric cancer patients in the diverse population and healthcare settings of Texas: The KidsCanSeq Study

| PRJNA713870 | ENA

CSER: Evaluating utility and improving implementation of genomic sequencing for pediatric cancer patients in the diverse population and healthcare settings of Texas: The KidsCanSeq Study

| PRJNA713871 | ENA

CSER: Genomic Diagnosis in Children with Developmental Delay

Project description:CSER: Genomic Diagnosis in Children with Developmental Delay

| PRJNA315714 | ENA