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Hypercapnia impairs fibroblast cell activity and promotes cellular differentiation

ABSTRACT: Hypercapnia impairs fibroblast cell activity and promotes cellular differentiation

PROVIDER: PRJNA691761 | ENA |

REPOSITORIES: ENA

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Hypercapnia impairs fibroblast cell activity and promotes cellular differentiation

Project description:Hypercapnia has deleterious effects on cell function, including inhibition of alveolar epithelial cells (AEC) and fibroblast proliferation without causing cell death. Classical studies and lineage-trace models demonstrated that fibroblast cells can affect the structurally and functionally distinct alveolar type 1 cells (AT1) and alveolar type 2 cells. This fibroblast cells reprogramming depends on certain signaling pathways that plays critical roles in tissue development and homeostasis throughout the organism lifespan.

2021-12-31 | GSE164733 | GEO

Hypercapnia impairs AT2 cell progenitor activity and promotes differentiation to AT1 cells

Project description:Hypercapnia impairs AT2 cell progenitor activity and promotes differentiation to AT1 cells

| PRJNA579691 | ENA

Hypercapnia impairs AT2 cell progenitor activity and promotes differentiation to AT1 cells

Project description:Hypercapnia has deleterious effects on cell function, including inhibition of alveolar epithelial cells (AEC) and fibroblast proliferation without causing cell death. Classical studies and lineage-trace models demonstrated that surfactant-producing AT2 cells can serve as stem cells for the structurally and functionally distinct alveolar type 1 cells (AT1) This AT2 reprogramming depends on Wnt/βcat signaling, a pathway that plays critical roles in tissue development and homeostasis throughout the organism lifespan. We found that high CO2 inhibits AT2 cell proliferation and self renewal, and promote their differentiation to ATEC and AT1 cells

2021-12-31 | GSE139426 | GEO

Disturbed intramitochondrial phosphatidic acid transport impairs cellular stress signaling

Project description:Disturbed intramitochondrial phosphatidic acid transport impairs cellular stress signaling

| PRJNA674653 | ENA

Towne induced changes to human foreskin fibroblast transcriptional activity.

Project description:Towne induced changes to human foreskin fibroblast transcriptional activity.

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Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity

Project description:Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity

| PRJNA838125 | ENA

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

Project description:MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

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Pericyte-fibroblast transition promotes tumor growth and metastasis

Project description:Vascular pericytes, an important cellular component, in the tumor microenvironment, are often associated with tumor vasculatures and their functions in cancer invasion and metastasis are poorly understood. Here we show that PDGF-BB induces pericyte fibroblast transition (designated as PFT), which significantly contributes to tumor invasion and metastasis. Gain- and loss-of-function experiments demonstrate that the PDGF-BB-PDGFRÎ² signaling promotes PFT in vitro and in in vivo tumors. Genome-wide expression analysis indicates that PDGF-BB-activated pericytes acquire mesenchymal progenitor features. Pharmacological inhibition and genetic deletion of PDGFRÎ² ablate the PDGF-BB-induced PFT. Genetic tracing of pericytes with two independent mouse strains, i.e., TN-AP-CreERT2:R26R-tdTomato and NG2:R26R-tdTomato, shows that PFT cells gains stromal fibroblast and myofibroblast markers in tumors. Importantly, co-implantation of PFT cells with less-invasive tumor cells in mice markedly promotes tumor dissemination and invasion, leading to an increased number of circulating tumor cells (CTCs) and metastasis. Our findings reveal a novel mechanism of vascular pericytes in PDGF-BB-promoted cancer invasion and metastasis by inducing PFT and thus targeting PFT may offer a new treatment option of cancer metastasis. Pericytes were isolated and treated with PDGF-BB or control for 1 or 5 days

2016-08-24 | E-GEOD-85955 | biostudies-arrayexpress

Effect of NKX2-5 or ETS1 on GATA4 pioneer activity [fibroblast]

Project description:Effect of NKX2-5 or ETS1 on GATA4 pioneer activity [fibroblast]

| PRJNA655132 | ENA

NRF2-dependent ECM - Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome

Project description:Nrf2-mediated fibroblast reprogramming drives cellular senescence by targeting the matrisome. ECM was isolated from WT and NRF2-/- mouse fibroblasts and analyzed by label-free quantification.

2018-07-23 | PXD007999 | Pride

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