Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profile of wild-type MCF10-A or rho0 MCF10-A cells after cellular irradiation

ABSTRACT: Gene expression profile of wild-type MCF10-A or rho0 MCF10-A cells after cellular irradiation

PROVIDER: PRJNA692725 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Gene expression profile of wild-type MCF10-A or rho0 MCF10-A cells after cellular irradiation

Project description:Goal is to uncover genes that fail to be activated by cellular irradiation when mitochondrial DNA is depleted in MCF10-A. To this end we delivered 20gy of ionizing radiation at 0.8gy/minute and waited 6 days. Total RNA was collected and DE genes were compared between wild-type irradiated cells and rho0 irradiated cells.

2021-02-24 | GSE164980 | GEO

Differential gene expression profiles between Parp-2-/- and wild-type hematopoietic stem/progenitors cell at basal and in response to 5 Gy gamma Irradiation (2.5 hours post-irradiation)

Project description:Gene expression profile between Parp-2-/- and wild-type hematopoietic stem/progenitor cells at basal and to the early response (2.5 hours) to 5 Gy total body irradiation

2013-08-06 | GSE42022 | GEO

Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

Project description:Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

| PRJNA793260 | ENA

Small intestinal tissue and epithelial regeneration after 12 Gy whole-body irradiation of C57BL/6 wild type mice

Project description:C57BL/6 wild type mice were exposed to 12 Gy whole-body irradiation. Before irradiation (t=0) and at t=24, 48 and 96 hours after irradiation, mice (n=10 per time point) were euthanized. From n=5 mice per time point RNA was isolated from small-intestinal (jejunum) tissue, from n=5 mice per time point RNA was isolated from EDTA-isolated epithelial cells from small-intestinal tissue (jejunum).

2021-07-09 | GSE179777 | GEO

Differential gene expression profiles between Parp-2-/- and wild-type hematopoietic stem/progenitors cell at basal and in response to 5 Gy gamma Irradiation (2.5 hours post-irradiation)

Project description:Gene expression profile between Parp-2-/- and wild-type hematopoietic stem/progenitor cells at basal and to the early response (2.5 hours) to 5 Gy total body irradiation We analyzed 2 arrays from each condition. Each samples represent a pool of at least 3 mice

2013-08-06 | E-GEOD-42022 | biostudies-arrayexpress

Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

Project description:Novel particle therapy was implemented into standard-of-care for cancer patients during the last years. However, experimental studies investigating cellular and molecular mechanisms are lacking although prognostic biomarker are urgently needed. The cancer stem cell (CSC)-related marker aldehyde dehydrogenase (ALDH) is known to impact on prostate cancer radiosensitivity through affecting defense against reactive oxygen species (ROS), reducing DNA damage repair and increasing cell survival. Surprisingly, we could show in a previous study that ionizing radiation itself enriches for ALDH-positive CSCs in a time- and dose-dependent manner through alteration in histone methylation. Within the present study, we investigated CSC marker dynamics upon proton beam irradiation and hypothesized that this novel particle therapy may have increased CSC targeting potential due to its increased ionization potential compared to conventional photon irradiation. However, we found that proton irradiation is affecting cellular dynamics and escape from cell death.

2021-12-31 | GSE192817 | GEO

Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity [methylation]

Project description:Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity [methylation]

| PRJNA793700 | ENA

Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity [methylation]

2022-01-03 | GSE192899 | GEO

MRG15 interactome upon UV irradiation

Project description:The aim of this analysis is to identify the difference between interaction partners of MRG15 wild type and Chromodomain and MRG domain mutants upon UV irradiation. Therefore, MRG15 wild type and mutants (N-terminal FLAG tag) were overexpressed in U2OS cells. After UV irradiation, immunoprecipitation of the constructs was performed using FLAG M2 affinity gel. The constructs were eluted from the beads with 3xFLAG peptide.

2023-07-03 | PXD043089 | Pride

Transcription profiling of mouse wild type and DNA repair-deficient primary dermal fibroblasts upon exposure to ultraviolet irradiation

Project description:Transcription profiling of wild type and DNA repair-deficient cells upon exposure to ultraviolet irradiation.

2009-04-01 | E-MEXP-1968 | biostudies-arrayexpress