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DFMO effect on Th17 and iTreg cells (ATAC-Seq)

ABSTRACT: DFMO effect on Th17 and iTreg cells (ATAC-Seq)

PROVIDER: PRJNA693243 | ENA |

REPOSITORIES: ENA

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DFMO effect on Th17 and iTreg cells (RNA-Seq)

Project description:DFMO effect on Th17 and iTreg cells (RNA-Seq)

| PRJNA681345 | ENA

DFMO effect on Th17 and iTreg cells (ATAC-Seq)

Project description:We studied the effects of polyamine pathway inhibitors on differentiation of nonpathogenic Th17 cellsin vitro. Here, we used difluoromethylornithine (DFMO), an irreversible inhibitor of ODC1, the enzyme that catalyzes the conversion of ornithine to putrescine.

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DFMO effect on Th17 and iTreg cells (RNA-Seq)

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Project description:To investigate the how TET1/3 remodels the chromatin landscape during iTreg cell differentiation and the role of autonomous IL-2 in this process, we performed ATAC-Seq on CD4 T cells that had been stimulated for 48hrs in the presence of TGF-b and in the presence or absence of exogenous IL-2.

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