Project description:Transcriptional profiling of mouse ipsilateral hippocampi at 24 hours after intra-amygdala kainic acid-induced status epilepticus followed by either Antagomir-134 or Scramble (control) treatment (intraperitoneal; 30 mg.kg-1)
Project description:Transcriptional profiling of N4 Ube3am-/p+ mice ipsilateral hippocampi at 24h after the last audiogenic stimulus (at postnatal day 27; out of three stimulus) of mice pre-treated with either scramble or antagomir-134 (Ant-134; 0.5 nmol; ICV).
Project description:Gene expression of murine repeatedly activated Th1 cells 36h, 48h and 72h after miR-31 inhibition using a specific antagomir (Antagomir-31) compared to a scrambled controll (Antagomir-SCR).
Project description:The circadian clock is an endogenous oscillator that drives daily rhythms in physiology, behavior and gene expression. The underlying mechanisms of circadian timekeeping are cell-autonomous and involve interconnecting transcription-translation feedback loops. The hippocampus plays an important role in spatial memory and the conversion of short-term to long-term memory. Several studies have reported the presence of a peripheral oscillator in the hippocampus, and have highlighted the importance of circadian regulation in memory formation. In this study we performed global quantitative proteome and phosphoproteome analyses of the murine hippocampus across the circadian cycle, applying spiked-in labeled reference and high accuracy mass spectrometry.
Project description:SOX2 is the main gene involved in anophthalmia. In order to identify genes regulated by SOX2 transcription factors (genes that could be good candidates to also be involved in ocular development), we studied transcriptomic profiles of murine genetically modified stem cells overexpressing the RAX gene (CCE-Rx cells) after transfection by a siRNA against SOX2 or a scramble siRNA. murine genetically modified stem cells overexpressing the RAX gene (CCE-Rx cells) after transfection by a siRNA against SOX2 or a scramble siRNA
Project description:We report a high depth single-cell combinatorial indexing (sci-)ATAC-seq map of the murine hippocampus from fresh and frozen tissue as well as cultured neurons