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Identification of enhancer-promoter contacts in squamous cancer cells [RNA-seq]

ABSTRACT: Identification of enhancer-promoter contacts in squamous cancer cells [RNA-seq]

PROVIDER: PRJNA699666 | ENA |

REPOSITORIES: ENA

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Identification of enhancer-promoter contacts in squamous cancer cells

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Project description:What controls enhancer-promoter communication to allow for cis-transcriptional regulation remains a mystery. Here we studied how transcriptional dynamics shapes enhancer-promoter contacts. We demonstrate that enhancer function is reflected in enhancer-promoter contacts frequency which highly depend on active transcription. Pol II pausing, which is widespread across metazoan enhancers and promoters, has a direct effect on focal enhancer-promoter contacts. We confirmed this effect by depleting NELFB, a subunit of the negative elongation factor complex and a pivotal factor in Pol II pausing. Moreover, the catalytic activity of PARP1, a regulator of transcription and chromatin condensation, stabilizes enhancer-promoter contacts globally, but can destabilize contacts by promoting Pol II escape from pausing. Based on these findings, we propose an updated model that couples transcription and enhancer-promoter contacts.

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Project description:Dynamic and stable enhancer-promoter contacts regulate terminal differentiation

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