Project description:To study the field cancerization effect, we screened systemic metastasis-related CNVs from morphologically normal colon tissues adjacent to colon cancer that had systemic metastasis. 89 systemic metastasis-related CNVs, mainly consisting of migration and invasion-, morphology-, cell death and survival-related pathways, were selected. Noticeably, LIM and senescent cell antigen-like domains 2 (LIMS 2, PINCH2) showed copy number amplification and up-regulation of mRNA expression in the non-relapsed group compared to the systemic relapse group. Colon cancer cells had lower expression of PINCH2 protein and mRNA compared with normal epithelial colon cells.

2013-02-14 | GSE44300 | GEO

Methylation data from healthy, adjacent normal and tumor colon cells

Project description:Methylation profiles of paired normal adjacent mucosa and tumor samples from 96 individuals and 48 healthy colon mucosae, were obtained through Illumina Infinium Human Methylation 450K BeadChip. This dataset is in the context of the COLONOMICS project and to query additional information you can visit the project website www.colonomics.org.

2020-05-10 | GSE131013 | GEO

Gene expression data from healthy, adjacent normal and tumor colon cells

Project description:Gene expression profiles of paired normal adjacent mucosa and tumor samples from 98 individuals and 50 healthy colon mucosae, were obtained through Affymetrix Human Genome U219 Arrays. This dataset is in the context of the COLONOMICS project and to query additional information you can visit the project website www.colonomics.org. Colon tumor and adjacent paired normal mucosa tissues samples used in this study were selected from a series of cases with a new diagnosis of colorectal adenocarcinoma histologically confirmed. Included cases were from a homogenous series of patients with more than three years of follow up, early stage (II), without neoadjuvant chemotherapy and microsatellite stable colon cancer. Additionally, samples of colon mucosa from 50 healthy donors without colonic lesions were obtained during colonoscopy.

2014-03-14 | E-GEOD-44076 | biostudies-arrayexpress

Gene expression data from healthy, adjacent normal and tumor colon cells

2014-03-14 | GSE44076 | GEO

DNA profiling of human normal colon tissues

2013-02-14 | E-GEOD-44300 | biostudies-arrayexpress

Methylation data from healthy, adjacent normal and tumor colon cells

Project description:Methylation data from healthy, adjacent normal and tumor colon cells

| PRJNA542323 | ENA

Differential gene expression between human colon cancers and the adjacent nomral colon tissues.

Project description:Differential gene expression between human colon cancers and the adjacent nomral colon tissues.

| PRJNA565188 | ENA