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Contextual cues from cancer cells govern CAF heterogeneity [scRNA-seq]

ABSTRACT: Contextual cues from cancer cells govern CAF heterogeneity [scRNA-seq]

PROVIDER: PRJNA701029 | ENA |

REPOSITORIES: ENA

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Contextual cues from cancer cells govern CAF heterogeneity

Project description:Contextual cues from cancer cells govern CAF heterogeneity

| PRJNA701033 | ENA

Contextual cues from cancer cells govern CAF heterogeneity [scRNA-seq]

Project description:Cancer cells function as primary architects of the tumor microenvironment. Yet, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneity is driven by lung adenocarcinoma (LUAD) cells at either end of the epithelial-to-mesenchymal transition (EMT) spectrum. LUAD cells that have high expression of the EMT-activating transcription factor ZEB1 reprogram CAFs through a ZEB1-dependent secretory program and direct CAFs to the tips of invasive projections through a ZEB1-driven CAF repulsion process. EMT, in turn, sensitizes LUAD cells to pro-metastatic signals from CAFs. Thus, CAFs respond to contextual cues from LUAD cells to promote metastasis.

2021-04-09 | GSE166479 | GEO

Contextual cues from cancer cells govern CAF heterogeneity [Bulk RNA-seq]

2021-04-09 | GSE166478 | GEO

Contextual cues from cancer cells govern CAF heterogeneity [Bulk RNA-seq]

Project description:Contextual cues from cancer cells govern CAF heterogeneity [Bulk RNA-seq]

| PRJNA701030 | ENA

Contextual cues from cancer cells govern CAF heterogeneity

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-04-08 | GSE166480 | GEO

10x and C1 CAF sequencing

Project description:Single-cell mRNA sequencing (scRNA-seq) study was conducted to to probe heterogeneity of human prostate CAF cells.

2020-03-16 | GSE123359 | GEO

aNOF vs. CAF

Project description:Compare the difference between pairwise aNOF and CAF samples for two patients patient #225: aNOF #225 vs CAF #225 patient #248: aNOF #248 vs CAF #248

2012-01-27 | E-GEOD-35249 | biostudies-arrayexpress

Human carcinoma-associated fibroblasts (CAF): co-culture with cancer cells vs. CAF only

Project description:Gene expression profiling of CAF co-cultured with human oral squamous cell carcinoma (OSCC) cells compared with mono-cultured CAF. To identify key molecular regulators expressed by carcinoma-associated fibroblasts (CAF) that promote cancer cell invasion, microarrays were performed by comparing co-cultured OSCC cells and CAF with monoculture controls. comparison 1: CAF co-cultured with OSCC vs. mono-cultured CAF comparison 2: OSCC co-cultured with CAF vs. mono-cultured OSCC 1.7X10(5) YD-10B OSCC cells and 1.7X10(5) CAF were seeded in the upper chamber and lower chamber, respectively, of 6-transwell plates containing collagen-coated 1 micrometer pore transmembrane filters (Becton Dickinson, Franklin Lakes, NJ, USA). Monoculture control samples were generated by culturing only CAF or OSCC on the same side of the filter as in the co-culture design.

2010-06-21 | E-GEOD-18532 | biostudies-arrayexpress

Gene expression in CAF-1 leaves

Project description:Chromatin assembly factor CAF-1 is conserved in all eukaryotes. In contrast to animals, plant CAF-1 is viable. Here we probe effects of loss of CAF-1 on the transcriptome of non-diving cells. Fully expanded rosette leaf 6 was collected from 10 35-d-old plants grown in short day photoperiods of wild type Col and CAF-1 mutants fas2-4 were used for RNA extraction.

2015-11-02 | E-MTAB-2376 | biostudies-arrayexpress

Human carcinoma-associated fibroblasts (CAF): co-culture with cancer cells vs. CAF only

2009-10-14 | GSE18532 | GEO

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