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RNA-seq of murine tibialis anterior muscle treated with AAV expressing AR isoform 2 (AR45) or AAV-GFP

ABSTRACT: RNA-seq of murine tibialis anterior muscle treated with AAV expressing AR isoform 2 (AR45) or AAV-GFP

PROVIDER: PRJNA701490 | ENA |

REPOSITORIES: ENA

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RNA-seq of murine tibialis anterior muscle treated with AAV expressing AR isoform 2 (AR45) or AAV-GFP

Project description:The goal of this study was to determine the transcriptomic response of AR-2 (AR45) overexpression in the TA muscles of the AR100Q murine model of SBMA (spinal and bulbar muscular atrophy). Conclusion: AAV-AR45 therapy resulted in a partial restoration of the SBMA-like expression signature compared with mock-treated controls.

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