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Transcriptome analysis of control and RBM6 KO cells before and after DNA damage

ABSTRACT: Transcriptome analysis of control and RBM6 KO cells before and after DNA damage

PROVIDER: PRJNA704004 | ENA |

REPOSITORIES: ENA

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Transcriptome analysis of control and RBM6 KO cells before and after DNA damage

Project description:Control and RBM6-KO MCF10A-Hras cells were subjected to RNA-sequencing before and after 12hrs exposure to 5Gy ionizing radiation (IR). Transcriptome analysis revealed a subset of genes that are differentially regulated in RBM6-KO cells compared to control cells. In addition, transcriptome of RBM6-KO cells after IR showed upregulation of DNA damage genes, suggesting impaired DNA repair compared to control cells.

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Expression data from fibroblasts BjhTERT-RhoA-KO and PC3 tumor cells after cocultivation and before

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