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Omics score: 1000

RNA-seq in QGY-7703 cell line before and after PRMT7 knockdown

ABSTRACT: RNA-seq in QGY-7703 cell line before and after PRMT7 knockdown

PROVIDER: PRJNA704649 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13777521_1.fastq.gz	Fastqsanger.gz
	SRR13777521_2.fastq.gz	Fastqsanger.gz
	SRR13777522_1.fastq.gz	Fastqsanger.gz
	SRR13777522_2.fastq.gz	Fastqsanger.gz
	SRR13777523_1.fastq.gz	Fastqsanger.gz

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Publications

An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.

Shen Ting T Ni Ting T Chen Jiaxuan J Chen Haitao H Ma Xiaopin X Cao Guangwen G Wu Tianzhi T Xie Haisheng H Zhou Bin B Wei Gang G Saiyin Hexige H Shen Suqin S Yu Peng P Xiao Qianyi Q Liu Hui H Gao Yuzheng Y Long Xidai X Yin Jianhua J Guo Yanfang Y Wu Jiaxue J Wei Gong-Hong GH Hou Jinlin J Jiang De-Ke DK

Nature communications 20220309 1

Most cancer causal variants are found in gene regulatory elements, e.g., enhancers. However, enhancer variants predisposing to hepatocellular carcinoma (HCC) remain unreported. Here we conduct a genome-wide survey of HCC-susceptible enhancer variants through a three-stage association study in 11,958 individuals and identify rs73613962 (T > G) within the intronic region of PRMT7 at 16q22.1 as a susceptibility locus of HCC (OR = 1.41, P = 6.02 × 10<sup>-10</sup>). An enhancer dual-luciferase assay ...[more]

PMID: 35264579

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