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RNA from 4T1 tumors in mice treated with miR-loaded EVs

ABSTRACT: RNA from 4T1 tumors in mice treated with miR-loaded EVs

PROVIDER: PRJNA705188 | ENA |

REPOSITORIES: ENA

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RNA from 4T1 tumors in mice treated with miR-loaded EVs

Project description:RNA was harvested from 4T1 tumors in mice treated with miR-loaded EVs

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Small RNA sequencing in cell and extracellular vesicles (EVs) of breast cancer 4T1 and 4TO7 cells

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Expression data from TKI258 treated 4T1 cells and 4T1 tumors

Project description:This SuperSeries is composed of the following subset Series: GSE19220: Expression data from TKI258 treated 4T1 cells GSE19221: Expression data from TKI258 treated 4T1 tumors Refer to individual Series

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4T1 breast tumors: SPARC knock down primary tumors vs. Control primary tumors vs. Lung metastasis foci

Project description:Comparative analysis of the transcriptome of primary tumors generated from 4T1 cells transduced with a lentiviral vector expressing a siRNA against murine SPARC (4T1-C18), primary tumors generated from 4T1 cells transduced with a lentiviral vector expressing a scramble sequence (4T1-SCR) or lung metastasis foci from 4T1-SCR tumor-bearing mice (4T1-SCR MTTS). Three experimental conditions, 4T1-C18, 4T1-SCR and 4T1-SCR MTTS. Biological replicates: 4 4T1-C18, 4 4T1-SCR, 4 4T1-SCR MTTS independently grown in different mice. 2 days-old tumors and 30 days old lung foci. One replicate per array. All microarrays were processed the same day

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Expression data from TKI258 treated 4T1 tumors

Project description:4T1 mouse mammary carcinoma cells have an autocrine FGFR active loop leading to constitutive activation of downstream signaling pathways. We found that FGFR inhibitors have a strong effect on 4T1 tumors in-vivo. We used microarray to understand the contribution of FGFR signaling to the tumor formation upon TKI258 treatment. 4T1 cells were injected in the 4th mammary gland of Balb/C mice. After 7 days, daily treatment with TKI258 or water was performed for 14 days. At the end of the experiment, the RNA were extracted from three individual tumors per condition and hybridized on Affimetrix microarrays.

2010-07-07 | E-GEOD-19221 | biostudies-arrayexpress

Proteomic analysis of extracellular vesicles (EVs) from 4T1 breast cancer cells upon paclitaxel treatment

Project description:Increasing pre-clinical data suggest that chemotherapy may elicit pro-metastatic responses in breast cancer models. Primary tumours release extracellular vesicles (EVs) that can facilitate the seeding and growth of metastatic cancer cells in distant organs, but the effects of chemotherapy on pro-metastatic EVs are poorly understood. The goal of the project was to analyse the protein content in EVs released by the mouse breast cancer cell line 4T1 after treatment with the chemotherapeutic agent paclitaxel (PTX) or its vehicle control cremophor (CREMO).

2019-01-02 | PXD010362 | Pride

Effects of miR-126/126* of cytokine/chemokine expression in tumor-derived 4T1 cells

Project description:In order to test the effects of metastasis suppressive miR-126/126* on primary tumor microenvironment, we designed a real-time PCR-based mouse cytokine/chemokine array containing 95 cytokines/chemokines and their receptors. Considering the possibility that production of cytokines/chemokines may be dependent on the interactions among different cell types within the tumor mass, we inoculated GFP-labeled 4T1 cells with a control vector or 4T1 cells with pri-miR-126 overexpression into the fat pad of BALB/c mice. 10 days later, we harvested the primary tumors, isolated GFP-positive cancer cells, and analyzed the expression levels of different cytokines/chemokines and their receptors in the cancer cells at the mRNA level using the cytokine array. qPCR gene expression profiling. Equal amount total RNA from each cell line was pooled prior to gene expression analysis.

2012-12-13 | E-GEOD-42885 | biostudies-arrayexpress

Expression data from TKI258 treated 4T1 tumors

2010-07-07 | GSE19221 | GEO

Single cell RNA-seq of 4T1-T vasculogenic mimicry-competent mammary tumors

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2023-07-26 | GSE230642 | GEO

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