Genomics

Dataset Information

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Single-cell RNA-Seq profiling of the mouse anorectal junction before, during, and after acute colitis


ABSTRACT: Single-cell RNA-Seq profiling of the mouse anorectal junction before, during, and after acute colitis

PROVIDER: PRJNA705910 | ENA |

REPOSITORIES: ENA

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Publications

Transitional Anal Cells Mediate Colonic Re-epithelialization in Colitis.

Liu Cambrian Y CY   Girish Nandini N   Gomez Marie L ML   Dubé Philip E PE   Washington M Kay MK   Simons Benjamin D BD   Polk D Brent DB  

Gastroenterology 20220225 7


<h4>Background & aims</h4>Epithelial wound healing is compromised and represents an unleveraged therapeutic target in inflammatory bowel disease (IBD). Intestinal epithelial cells exhibit plasticity that facilitates dedifferentiation and repair during the response to injury. However, it is not known whether epithelial cells of a neighboring organ can be activated to mediate re-epithelialization in acute colitis. Histological findings of a permanent squamous tissue structure in the distal colon i  ...[more]

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