Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Sox8 reprograms ectoderm into ear vesicles and associated neurons [ChIP-seq]

ABSTRACT: Sox8 reprograms ectoderm into ear vesicles and associated neurons [ChIP-seq]

PROVIDER: PRJNA705998 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Sox8 reprograms ectoderm into ear vesicles and associated neurons [Lmx1aE1_rnaseq]

Project description:Sox8 reprograms ectoderm into ear vesicles and associated neurons [Lmx1aE1_rnaseq]

| PRJNA705997 | ENA

Sox8 reprograms ectoderm into ear vesicles and associated neurons [Sox8OE_rnaseq]

Project description:Sox8 reprograms ectoderm into ear vesicles and associated neurons [Sox8OE_rnaseq]

| PRJNA706000 | ENA

Sox8 reprograms ectoderm into ear vesicles and associated neurons [Sox8OE_rnaseq]

Project description:The vertebrate inner ear arises from a pool of progenitors with the potential to give rise to all the sense organs and cranial ganglia of the head1-6. Here we explore the molecular mechanisms that control ear specification from these progenitors. Using a multi-omics approach combined with loss-of-function experiments we identify a core transcriptional circuit that imparts ear identity, along with non-coding elements that integrate this information. This analysis places the transcription factor Sox8 at the top of the ear determination network. Introducing Sox8 into cranial ectoderm not only converts non-ear cells into ear progenitors, but also activates the cellular programmes for ear morphogenesis and neurogenesis. Thus, Sox8 emerges as a master regulator of ear identity and may be a key factor for sense organ cell reprogramming.

2022-07-06 | GSE168087 | GEO

Sox8 reprograms ectoderm into ear vesicles and associated neurons [Lmx1aE1_rnaseq]

2022-07-06 | GSE168084 | GEO

Sox8 reprograms ectoderm into ear vesicles and associated neurons [ATAC-seq]

2022-07-06 | GSE168082 | GEO

Sox8 reprograms ectoderm into ear vesicles and associated neurons [ChIP-seq]

2022-07-06 | GSE168083 | GEO

Sox8 reprograms ectoderm into ear vesicles and associated neurons [ATAC-seq]

Project description:Sox8 reprograms ectoderm into ear vesicles and associated neurons [ATAC-seq]

| PRJNA705991 | ENA

Sox8 reprogram ectoderm into ear vesicles and auditory neurons [smartseq2]

2022-07-06 | GSE168088 | GEO