Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RORα is critical for mTORC1 activity in T cell-mediated colitis [16S rRNA-seq]

ABSTRACT: RORα is critical for mTORC1 activity in T cell-mediated colitis [16S rRNA-seq]

PROVIDER: PRJNA706571 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

RORα is critical for mTORC1 activity in T cell-mediated colitis [16S rRNA-seq]

Project description:Inflammatory bowel disease (IBD) is multi-factorial chronic intestinal inflammation driven by pathogenic T cells. The mechanisms underlying colitis pathogenicity and anti-TNF therapy resistance are not fully understood. Here we demonstrate that RORα is highly expressed in active UC patients, particularly in those non-responsive to anti-TNF treatment. Rorα deficient CD4+ T cells could not induce severe gut inflammation in a T cell transfer colitis model. Mechanistically, RORα regulated T cell infiltration in colon by promoting T cell migration and inhibiting T cell apoptosis. Meanwhile, genome-wide occupancy and transcriptome analysis revealed that RORα promoted mTORC1 activation. mTORC1 signaling, also hyperactivated in active UC patients, was necessary for T cell-mediated colitis.

2021-07-28 | GSE168218 | GEO

RORα is critical for mTORC1 activity in T cell-mediated colitis [ChIP-seq]

2021-07-28 | GSE168217 | GEO

RORα is critical for mTORC1 activity in T cell-mediated colitis [RNA-seq]

2021-07-28 | GSE168216 | GEO

RORα is critical for mTORC1 activity in T cell-mediated colitis.

Project description:RORα is critical for mTORC1 activity in T cell-mediated colitis.

| PRJNA706568 | ENA

RORα is critical for mTORC1 activity in T cell-mediated colitis [ChIP-seq]

Project description:RORα is critical for mTORC1 activity in T cell-mediated colitis [ChIP-seq]

| PRJNA706572 | ENA

RORα is critical for mTORC1 activity in T cell-mediated colitis [RNA-seq]

Project description:RORα is critical for mTORC1 activity in T cell-mediated colitis [RNA-seq]

| PRJNA706573 | ENA

RORα is critical for mTORC1 activity in T cell-mediated colitis.

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-07-28 | GSE168219 | GEO

Screen mRNAs specifically regulated by mTORC1 in colon epithelial cells from mice with dextran sulfate sodium (DSS)-induced experimental colitis

Project description:To screen mRNAs specifically regulated by mTORC1, a global mRNA expression profile in colon epithelial cells (CECs) from mice with or without CECs-specific TSC1 knockout (KO) was developed using microarray. Wile-type or CECs-specific TSC1 KO mice with experimental colitis were sacrificed, with CECs harvested and subjected to total RNA extraction.

2015-11-05 | E-GEOD-74674 | biostudies-arrayexpress

The identification of genes altered by RORα in progression of non-alcoholic steatohepatitis (NASH)

Project description:Purpose: To identify the target genes of RORα associated with development of NASH Methods: RNA isolation for sequencing analysis from liver tissues of High fat diet (HFD)-fed RORα-LKO and RORα f/f mice and mRNA-sequencing Conclusion: When calcuated by dividing the normalized read count of HFD-fed RORα-LKO by that of RORαf/f,.there are 8505 genes altered by RORα deletion (cut-off, 0.8-fold, 1.5-fold).

2019-12-03 | GSE90844 | GEO

RORɣt and RORα Signature Genes in Human Th17 Cells

Project description:In an effort to study gene expression modulated by RORɣt and RORα in human Th17 cells, global gene expression of human CD4 T cells activated under Th17 skewing conditions was profiled by RNA sequencing. RORɣt and RORα signature genes were identified in these Th17 cells treated with specific siRNAs to knock down RORɣt or RORα expression. In addition, selective small molecule RORɣt modulators were also utilized as pharmacological tools in RORɣt signature gene identification.

2017-09-14 | GSE103844 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data