Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

ABSTRACT: RNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

PROVIDER: PRJNA707561 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

scRNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

Project description:scRNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

| PRJNA707020 | ENA

scRNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

Project description:Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a WWTR1-CAMTA1 fusion gene in greater than 90% of cases. Using an adaptation of the FLEx system, we generated a genetically engineered mouse model of EHE whereby the endogenous Wwtr1 Locus is replaced with an Wwtr1-Camta1 locus. Tumors generated from this mouse model were dissociated and a 10X genomics library preparation was performed. The barcoded library was then deep sequenced.

2021-03-25 | GSE168354 | GEO

RNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

Project description:Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a WWTR1-CAMTA1 fusion gene in greater than 90% of cases. Using an adaptation of the FLEx system, we generated a genetically engineered mouse model of EHE whereby the endogenous Wwtr1 Locus is replaced with an Wwtr1-Camta1 locus. RNA was isolated from the resultant tumors and from control liver tissue and RNA sequencing was performed. Cross species analysis between human and mice tumors demonstrated murine EHE maintains the defining transcriptional features of human EHE.

2021-03-25 | GSE168494 | GEO

RNA-seq of Human Epithelioid Hemangioendothelioma and genetically engineered mouse model of EHE

Project description:RNA-seq of Human Epithelioid Hemangioendothelioma and genetically engineered mouse model of EHE

| PRJNA707558 | ENA

Expression profiles of genetically engineered mouse model tumors (GNA11 Q209L and GNA11 Q209L Bap1 KO)

Project description:RNA-seq of end-point tumors harvested from genetically engineered mouse melanoma model

2018-01-31 | GSE97223 | GEO

RNAseq of genetically engineered mouse model (GEMM) tumors

Project description:We report the expression profiling of lung adenocarcinoma tumors arising from genetically engineered mice with activation of KRAS(K) and loss of either SMARCA4 (S), p53(P) or both.

2018-06-17 | GSE94927 | GEO

RNA sequencing of genetically engineered mouse model lung tumors and normal mouse lung.

Project description:Genetically engineered mouse models (GEMM) of cancer are powerful tools to study multiple aspects of caner biology. We developed a novel GEMM for lung squamous cell carcinoma (LSCC) by genetically combining overexpression of Sox2 with loss of Lkb1: Rosa26LSL-Sox2-IRES-GFP;Lkb1fl/fl (SL). We compared gene expression profiles of SL lung tumors with normal mouse lung tissue, mouse lung adenocarcinoma (LADC) tumors from KrasLSL-G12D/+;Trp53fl/fl (KP), mouse LSCC tumors from Lkb1fl/fl;Ptenfl/fl (LP) model as well as Lenti-Sox2-Cre Lkb1fl/fl.

2018-10-16 | GSE118246 | GEO

RNA sequencing of genetically engineered mouse model lung tumors and normal mouse lung.

Project description:RNA sequencing of genetically engineered mouse model lung tumors and normal mouse lung.

| PRJNA484951 | ENA

Transcription profiling of synovial sarcoma-like tumors induced in a genetically engineered mouse model

Project description:Synovial sarcoma-like tumors were generated in mice by conditionally expressing the human t(X;18) translocation-derived SYT-SSX2 fusion protein. Using a Tamoxifen-inducible CreER system, we show here that sporadic expression of SYT-SSX2 across multiple tissue types leads to exclusive formation of synovial sarcoma-like tumors while its widespread expression is lethal. CreER-based sporadic expression both avoids the severe early developmental phenotypes associated with widespread SYT-SSX2 expression and better models natural pathogenesis of cancers where transformed cells usually arise within an environment of largely normal cells. Experiment Overall Design: Genetically engineered mice capable of conditionally expressing the human synovial sarcoma-associated SYT-SSX2 fusion oncogene were mated with genetically engineered mice expressing the CreER fusion protein from ROSA locus. The progenies harboring both CreER and SYT-SSX2 were followed up with or without tamoxifen injection. Tumors were generated in these mice that were dissected out, RNA extracted, and subjected to expression profiling by microarray analysis.

2009-04-24 | E-GEOD-14469 | biostudies-arrayexpress

Modeling melanoma resistance in a genetically engineered mouse model

Project description:Modeling melanoma resistance in a genetically engineered mouse model

| PRJNA650202 | ENA