Project description:Tolypocladium guangdongense has a similar metabolite profile to Ophiocordyceps sinensis, a highly regarded fungus used for traditional Chinese medicine with high nutritional and medicinal value. Although the genome sequence of T. guangdongense has been reported, relatively little is known about the regulatory networks for fruiting body development and about the metabolite biosynthesis pathways. In order to address this, an analysis of proteome at differentially developmental stages of T. guangdongense was performed. Many heat shock proteins, transcription factors and proteins related to active ingredients were differentially expressed during the developmental process. These data could be meaningful and useful for studying the molecular mechanisms of fungal development, and for the industrial and medicinal application of macro-fungi.
Project description:Muconic acid production from engineered Corynebacterium glutamicum. Gene expression analysis in the pathway redesigned Corynebacterium glutamicum
