Genomics

Dataset Information

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Transcriptomic Analysis of Human Epidermal Keratinocytes Stimulated with TWEAK, TNF and IL-17A


ABSTRACT: Transcriptomic Analysis of Human Epidermal Keratinocytes Stimulated with TWEAK, TNF and IL-17A

PROVIDER: PRJNA718582 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR14108900_1.fastq.gz Fastqsanger.gz
SRR14108900_2.fastq.gz Fastqsanger.gz
SRR14108901_1.fastq.gz Fastqsanger.gz
SRR14108901_2.fastq.gz Fastqsanger.gz
SRR14108902_1.fastq.gz Fastqsanger.gz
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Publications

TWEAK functions with TNF and IL-17 on keratinocytes and is a potential target for psoriasis therapy.

Gupta Rinkesh K RK   Gracias Donald T DT   Figueroa Daniela Salgado DS   Miki Haruka H   Miller Jacqueline J   Fung Kai K   Ay Ferhat F   Burkly Linda L   Croft Michael M  

Science immunology 20211119 65


TNF and IL-17 are two cytokines that drive dysregulated keratinocyte activity, and their targeting is highly efficacious in patients with psoriasis, but whether these molecules act with other inflammatory factors is not clear. Here, we show that mice having a keratinocyte-specific deletion of Fn14 (<i>Tnfrsf12a</i>), the receptor for the TNF superfamily cytokine TWEAK (<i>Tnfsf12</i>), displayed reduced imiquimod-induced skin inflammation, including diminished epidermal hyperplasia and less expr  ...[more]

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