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Genomic and evolutionary classification of lung cancer in never smokers

ABSTRACT: Genomic and evolutionary classification of lung cancer in never smokers

PROVIDER: PRJNA719412 | ENA |

REPOSITORIES: ENA

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Genomic and evolutionary classification of lung cancer in never smokers

Project description:Lung cancer in never smokers (LCINS) is a common cause of cancer mortality, but is poorly characterized. Here we show, through high coverage whole genome sequencing of 232 tumors (Sherlock-Lung study), that LCINS can be separated into three subtypes, defined by somatic copy number aberrations. While the dominant subtype (‘piano’), rarely found in lung cancer from smokers, is characterized by quiet copy number profiles, the other subtypes are associated with specific arm-level amplifications and EGFR mutations (‘mezzo-forte’), and whole genome doubling (‘forte’). Piano tumors feature somatic UBA1 mutations, germline AR variants, and stem cell-like properties, including low mutational burden, infrequent TP53 alterations, high intra-tumor heterogeneity, long telomeres, and slow growth as suggested by the occurrence of cancer driver genes decades prior to tumor diagnosis. To assess the stem cell-like features in piano tumors, we performed bulk RNA-seq from our Sherlock-Lung study including 35 adenocarcinomas (16 Piano, 8 Mezzo-forte, 11 Forte) and 32 tumor-paired normal lung tissue. We compared expression of gene sets included in differnt stem-cell signatures and and the finding suggests that less differentiated and a lineage infidelity in paino subtype, which could be the signs of stemness.

2021-06-22 | GSE171415 | GEO

Comparative genomic hybridization of human lung adenocarcinoma in never smokers

Project description:CGH array in Lung Adenocarcinoma in Never Smokers

2010-12-31 | E-TABM-926 | biostudies-arrayexpress

CIT - Homo sapiens - APUP - Genomic aberrations in Lung Adenocarcinoma in Never Smokers

Project description:41 lung adenocarcinoma from never-smokers hybridized on Illumina SNP arrays on 13 HumanCNV370-Quadv3 chips. High-resolution array comparative genomic hybridization analysis of lung adenocarcinoma in 41 never smokers for identification of new minimal common regions (MCR) of gain or loss. The SNP array analysis validated copy-number aberrations and revealed that RB1 and WRN were altered by recurrent copy-neutral loss of heterozygosity.The present study has uncovered new aberrations containing cancer genes. The oncogene FUS is a candidate gene in the 16p region that is frequently gained in never smokers. Multiple genetic pathways defined by gains of MYC, deletions of RB1 and WRN or gains on 7p and 7q are involved in lung adenocarcinoma in never smokers. A 'Cartes d'Identite des Tumeurs' (CIT) project from the French National League Against Cancer (http://cit.ligue-cancer.net) 41 samples hybridized on Illumina SNP arrays. Submitter : Fabien PETEL petelf@ligue-cancer.net . Project leader : Pr Pierre FOURET pierre.fouret@psl.aphp.fr

2011-07-28 | E-TABM-1169 | biostudies-arrayexpress

Genomic study of lung adenocarcinoma in young never-smokers

Project description:Mutational profiling of LUAC in young never-smokers

| PRJEB23833 | ENA

Genomic study of lung adenocarcinoma in young never-smokers

Project description:Genomic study of lung adenocarcinoma in young never-smokers

| PRJEB23826 | ENA

Lung Cancer Genetic Study among Asian Never Smokers

Project description:Lung Cancer Genetic Study among Asian Never Smokers

| PRJNA705757 | ENA

Lung Cancer Genetic Study among Asian Never Smokers

Project description:Lung Cancer Genetic Study among Asian Never Smokers

| PRJNA705758 | ENA

Integrative analyses of lung cancer in never smokers

Project description:Integrative analyses of lung cancer in never smokers

| PRJNA492373 | ENA

Integrative analyses of lung cancer in never smokers

Project description:Integrative analyses of lung cancer in never smokers

| PRJNA492374 | ENA

Proteomic and Genomic Profiling of Bronchial Epithelial Cells in Never and Current Smokers

Project description:Comparison of gene and protein expression in the large airway epithelium of never and current smokers. Keywords: gene expression array-based (RNA / in situ oligonucleotide)

2009-04-10 | GSE4635 | GEO

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