Genomics

Dataset Information

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RNA-sequence on testes of wild type C57BL/6J, ARLmon/Y and AR-/Y mice


ABSTRACT: RNA-sequence on testes of wild type C57BL/6J, ARLmon/Y and AR-/Y mice

PROVIDER: PRJNA721722 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR14232275.fastq.gz Fastqsanger.gz
SRR14232276.fastq.gz Fastqsanger.gz
SRR14232277.fastq.gz Fastqsanger.gz
SRR14232278.fastq.gz Fastqsanger.gz
SRR14232279.fastq.gz Fastqsanger.gz
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Publications


Whereas dimerization of the DNA-binding domain of the androgen receptor (AR) plays an evident role in recognizing bipartite response elements, the contribution of the dimerization of the ligand-binding domain (LBD) to the correct functioning of the AR remains unclear. Here, we describe a mouse model with disrupted dimerization of the AR LBD (AR<sup>Lmon/Y</sup> ). The disruptive effect of the mutation is demonstrated by the feminized phenotype, absence of male accessory sex glands, and strongly  ...[more]

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