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CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function

ABSTRACT: CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function

PROVIDER: PRJNA722298 | ENA |

REPOSITORIES: ENA

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CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function [Smart-seq]

Project description:CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function [Smart-seq]

| PRJNA722297 | ENA

CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function [10X Genomics]

Project description:CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function [10X Genomics]

| PRJNA722299 | ENA

CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function

Project description:Clinically important broadly reactive B cells evolve during multiple infections. The phenotype and function of B cells re-activated after secondary infection is different compared to B cells activated after a primary infection. Here we studied CD27highCD38high plasmablasts from patients with a primary or secondary dengue virus infection. Three transcriptionally and functionally distinct plasmablast clusters were identified. The largest cluster 0/1 was plasma cell-related and contained cells coding for virus serotype cross-reactive antibodies of the IgG1 isotype, consistent with memory B cell activation during an extrafollicular response. In contrast, cells in clusters 2 and 3 expressed low levels of antibody genes and high levels of genes associated with oxidative phosphorylation, EIF2 pathway and mitochondrial dysfunction. Clusters 2 and 3, which we name T cell-dependent plasmablasts, showed a transcriptional footprint of T cell help, in line with activation from either naÃƒÂ¯ve B cells or memory B cells. Our results contribute to the understanding of the parallel B cell activation events that occur in humans after natural primary and secondary infection.

| EGAS00001005258 | EGA

CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function [Smart-seq]

Project description:Using Smart-seq2 single cell sequencing we reported that plasmablasts from dengue-infected individuals separate into 4 distinct clusters with distinct function.

2021-04-16 | GSE172176 | GEO

CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function [10X Genomics]

Project description:Using 10X Genomics we identified B cells with a plasmablasts signature (based on CD38, CD27 and PRDM1 expression) and extract these cells to assign them to our Smart-seq analysis run in parallel.

2021-04-16 | GSE172179 | GEO

CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-04-16 | GSE172180 | GEO

CD27<sup>hi</sup>CD38<sup>hi</sup> plasmablasts are activated B cells of mixed origin with distinct function.

Project description: Not available

| S-EPMC8169951 | biostudies-literature

PD-1highCXCR5–CD4+ Peripheral Helper T (Tph) cells Promote CXCR3+ Plasmablasts in the early phase of COVID-19

Project description:T cell–B cell interaction is the key immune response to protect host from severe viral infection. We used COVID-19 as a model of acute viral infections and analyzed CD4+ T cell subsets associated with plasmablasts expansion and clinical outcome. Peripheral helper T cells (Tph, denoted as PD-1highCXCR5–CD4+ T cells) were significantly increased, as were plasmablasts. Tph cells exhibited “B-cell help” signatures and induced plasmablasts differentiation in vitro. Expanded plasmablasts showed increased CXCR3 expression, which is positively correlated with higher frequency of activated Tph cells and better clinical outcome. These results elucidate a critical role for Tph cells in regulating protective B cell response during acute viral infection.

2023-01-05 | GSE214624 | GEO

CTCF binding in B cells and Plasmablasts

Project description:The mammalian CCCTC-binding factor (CTCF) regulates gene expression through the formation of higher order chromatin structures. Recent evidence has implicated a role for CTCF in regulating gene expression in the human MHCII locus. To investigate the role of CTCF in murine MHCII gene expression we mapped CTCF binding sites in B cells (MHCII+ cells) and Plasmablasts which are differentiated B cells that have silenced MHCII gene expression. These observations lead to the identification of differential CTCF binding during differentiation in these cell types and suggest mechanims of MHCII gene regulation. Comparison of CTCF binding in B cells and Plasmablasts in mice using ChIP-seq

2014-02-05 | E-GEOD-44637 | biostudies-arrayexpress

Single cell paired heavy- and light-chain immunoglobulin sequencing of sorted Lyme disease plasmablasts

Project description:Lyme disease (Borrelia burgdorferi infection) is increasingly recognized as a significant source of morbidity world-wide. Here, we investigated B cell responses to Lyme disease through barcode-enabled single cell sequencing of activated B cells (plasmablasts) sorted from PBMCs. Bulk immunglobulin heavy-chain sequencing from this project has also been separately deposited. Additional information regarding patient characteristics and overlap with other data from the SLICE study is available upon request.

2018-12-21 | GSE114309 | GEO

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