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Transcriptomic data from lymphocytic choriomeningitis virus-infected and mock-infected A549 cells

ABSTRACT: Transcriptomic data from lymphocytic choriomeningitis virus-infected and mock-infected A549 cells

PROVIDER: PRJNA723742 | ENA |

REPOSITORIES: ENA

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Transcriptomic data from lymphocytic choriomeningitis virus-infected and mock-infected A549 cells

Project description:We reported the transcriptomic analysis on A549 cells infected with lymphocytic choriomeningitis virus (LCMV).

2021-04-23 | GSE173072 | GEO

Transcription profiling of human A549 epithelial cells infected with polio virus or mock infected to compare Nanostring and Affymetrix technologies

Project description:Mock and poliovirus infected A549 cells were used as model system to assess Nanostring's technology for detecting mRNA transcripts, linearity of signal, reproducibility and fold change measurements. As a comparison, the same samples were measured using Affymetrix U133 2.0 plus arrays and several genes were followed up using RT-PCR. All samples for all platforms were performed in triplicate

2008-02-17 | E-MEXP-1072 | biostudies-arrayexpress

Expression data from A549 cell line infected with influenza A virus (IAV) and treated with/without Itaconate

Project description:Analysis of gene expression in A549 cells infected with influenza A virus or Mock and treated with Itaconic acid (IA), or Dimethyl itaconate (DI) to investigate the effects itaconate have on transcriptional response in A549 cells. We particularly looked at anti-inflammatory effects of itaconate in inflammation followed by Influenza A virus infection.

2021-10-31 | GSE162260 | GEO

Transcriptome analysis of HEK-293, A549 and HRT18 cells infected with shaan virus

Project description:propose: The goals of this study are viral transcript of host cells infected with shaan virus and host cell responses in HEK293, A549 and HRT18 infected with shaan virus. Methods: We infected the virus at an MOI of 0.5 to human tissues-derived cell lines including HEK-293, A549 and HRT18. The infected cells were harvested at 24 hours post infection, and a total RNA was extracted from the harvested cells with Trizol LS reagent. The trimmed reads were mapped to shaan virus genome or GRCh37 human genomic DNA reference. The differentially expressed genes (DEGs) between the virus-infected and mock-infected cells were calculated based on the fold changes of FPKM per each gene. Result: Viral transcripts were expressed differentially depending on the viral genes, it is obvious that the nucleocapsid (N) transcript was most expressed in all infected cells. Gene ontology enrichment analysis based on the DEGs revealed that HEK-293, A549 and HRT18 cells highly expressed the genes related to the antiviral defence system and innate immune response in response to the shaan virus infection. Conclusion: In this study, we describe transcriptome data from the shaan virus-infected cells. The inferred DEGs and their related biological functions can be further investigated to understand the shaanvirus-host interaction.

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Proteins modulated during persistent lymphocytic choriomeningitis virus infection

Project description:The experimental data indicate that during a persistent infection, lymphocytic choriomeningitis virus (LCMV) may both directly or indirectly modulate the regulatory cellular processes and alter the cellular functions that are not critical for the survival, but are needed for the homeostasis in the organism. Two-dimensional differential in-gel electrophoresis (2D-DIGE) and MALDI-TOF MS/MS analyses were used to determine the cellular proteome response of HeLa cell line to persistent LCMV infection. Quantitative analysis revealed 24 differentially abundant proteins, half of which were up-regulated and the rest down-regulated. Functional categorization showed that LCMV-responsive proteins were mainly involved in metabolism, stress and defense responses. Among identified proteins, significant changes were found for peroxiredoxins, family of antioxidant enzymes. Decreased amount of these antioxidant proteins was accompanied with the elevation of ROS content in infected cells.

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Gene Expression Data from Influenza A Virus-Infected and Mock-infected A549 Human Aveolar Epithelial Carcinoma Cells with Exposure to Mouse Eosinophils.

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Porcine macrophages: ASFV-infected vs. mock-infected

Project description:Porcine macrophages: ASFV-infected vs. mock-infected

| PRJNA549440 | ENA

Porcine macrophages: ASFV-infected vs. mock-infected

Project description:Transcriptional profiling of porcine macrophages infected with Afraican swine fever virus (ASFV) infected cells and mock infection was conducted in this experiment.

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Gene Expression Data from Influenza A Virus-Infected and Mock-infected Mouse Eosinophils

Project description:Eosinophils are terminally differentiated granulocytes that recently have been shown to become infected with Influenza A Virus (IAV). Here, we investigate transcriptional changes that occur to bone marrow-derived eosinophils following exposure to IAV. Global changes in the transcriptome of bone marrow derived mouse eosiniphils were assessed following mock- and Influenza A virus-infection using Affymetrix mouse gene 2.0 ST microarrays.

2020-05-01 | GSE140580 | GEO

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