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Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells

ABSTRACT: Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells

PROVIDER: PRJNA727010 | ENA |

REPOSITORIES: ENA

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Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells.

Project description: Not available

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Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells

Project description:GBM cells were treated with GAL3 shRNA vs sh ctrl. Gal3 forms a complex with Rab10 to potentiate macropinocytosis in the mesenchymal subpopulation of GBM tumors

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A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures

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Gene expression profiling of patient-derived glioblastoma stem cell cultures

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Gene expression profile of healthy-donor peripheral monocytes, glioblastoma-patient peripheral monocytes, and glioblastoma-infiltrating myeloid cells

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Project description:Galectin-1 (Gal-1) and Galectin-3 (Gal-3) are conserved carbohydrate-binding proteins that also display RNA-binding activity. We generated mouse embryonic stem cells (mESC) constitutively depleted of Gal-1 and/or Gal-3 using CRISPR-Cas9, and assessed the transcriptomic effects of the individual or concomitant depletion of Gal-1 and Gal-3 in mESCs differentiated by deprivation of the leukaemia inhibitory factor (LIF) for 7 days. Wild-type cells were employed as control.

2023-05-27 | E-MTAB-9262 | biostudies-arrayexpress

A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures

Project description:Glioblastoma (GBM) is the most frequent and deadly primary malignant brain tumor. Hallmarks are extensive intra- and inter-tumor heterogeneity and highly invasive growth, which provide great challenges for treatment. Efficient therapy is lacking for GBM and the majority of patients survive less than one year from diagnosis. GBM progression and recurrence is caused by treatment-resistant glioblastoma stem cells (GSCs). GSC cultures are considered important models to use in target identification and drug screening. The current state of the art method to isolate and maintain GSC cultures that faithfully mimic the primary tumor, is to use serum-free (SF) media conditions developed for neural stem cells (NSCs). Here we have investigated the outcome of explanting 230 consecutively collected GBM patient samples under both SF and standard, serum-containing media conditions. The establishment of maintainable SF cultures (SFCs) was most frequent, but for a subgroup of GBM specimens a viable culture could only be established in serum-containing media, called exclusive serum culture (ESC). ESCs expressed nestin and SOX2, and displayed all functional characteristics of GSCs, i.e. extended proliferation, sustained self-renewal and orthotopic tumor initiation. Once adapted to the in vitro milieu they were also sustainable in SF media. Molecular analyses showed that ESCs formed a discrete group that was most related to the mesenchymal GBM subtype. This distinct subgroup of GBM that had evaded modeling under SF conditions provide unique cell models of GBM intertumor heterogeneity.

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2014-09-17 | E-GEOD-61445 | biostudies-arrayexpress

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