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The transcriptome of paired major and minor salivary gland tissue in patients with primary Sjögren's syndrome

ABSTRACT: The transcriptome of paired major and minor salivary gland tissue in patients with primary Sjögren's syndrome

PROVIDER: PRJNA727106 | ENA |

REPOSITORIES: ENA

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The transcriptome of paired major and minor salivary gland tissue in patients with primary Sjögren's syndrome

Project description:While all salivary glands (SGs) can be involved in primary Sjögren’s syndrome (pSS), their respective role in pathogenesis remains unclear. To assess immunopathway activation in paired parotid and labial gland tissue from biopsy-positive and biopsy-negative pSS and non-SS sicca patients, paraffin-embedded, paired parotid and labial salivary gland tissue and peripheral blood mononuclear cells were obtained from 39 pSS and 20 non-SS sicca patients. The patients were subdivided based on fulfillment of ACR-EULAR criteria and histopathology and the samples were analyzed for differentially expressed genes (DEGs). The principal component analysis of SG gene expression could only separate biopsy-positive pSS from non-SS sicca patients. However, when comparing the transcriptome of biopsy-positive pSS and biopsy-negative non-SS sicca patients, 1235 and 624 DEGs (FDR<-1 or >1) were identified for parotid and labial glands, respectively. The number of DEGs between biopsy negative pSS and non-SS sicca patients was scarce. The overall, transcript expression levels correlated strongly between parotid and labial glands (R2=0.86, p‐value<0.0001). Gene signatures present in both glands of biopsy‐positive pSS patients included IFN‐α signaling, IL-12/IL-18 signaling, CD3/CD28 T-cell activation, CD40 signaling in B-cells, DN2 B-cells, and FcRL4+ B-cells. Signature scores varied considerably amongst pSS patients. In conclusion, the transcriptomes of paired major and minor SGs in pSS were overall comparable, although significant inter-individual heterogeneity in immunopathway activation existed. The SG transcriptome of biopsy-negative pSS was indistinguishable from non-SS sicca patients. The different patterns of SG immunopathway activation in pSS argue for personalized treatment approaches.

2021-05-05 | GSE173808 | GEO

The transcriptome of paired major and minor salivary gland tissue in patients with primary Sjögren's syndrome

2022-07-16 | GSE208260 | GEO

The transcriptome of paired major and minor salivary gland tissue in patients with primary Sjögren's syndrome

Project description:The transcriptome of paired major and minor salivary gland tissue in patients with primary Sjögren's syndrome

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Epigenetic Signatures of Salivary Gland Inflammation in Sjögren's Syndrome.

Project description:Genome wide DNA methylation profiling of human labial salivary gland (LSG) biopsy samples obtained from 28 female members of the Sjögren's International Collaborative Clinical Alliance (SICCA) Registry. The Illumina HumanMethylation450 BeadChip platform was used to obtain DNA methylation profiles across more than 450,000 highly informative CpG sites. Samples included 15 non-case glands, and 13 glands from patients with Sjögren's Syndrome.

2018-02-02 | GSE110007 | GEO

Epigenetic Signatures of Salivary Gland Inflammation in Sjögren's Syndrome.

Project description:Epigenetic Signatures of Salivary Gland Inflammation in Sjögren's Syndrome.

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Gene expression in minor salivary gland of patients with Sjogren's syndrome (SS) and control

Project description:To study the gene expression profile of salivary glands with varying degrees of inflammation in Sjogren's and non Sjogren's patients Total mRNA was extracted from whole minor salivary glands of patients with SS and control

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Gene expression in minor salivary gland of female patients with primary Sjögren’s syndrome (pSS) and healthy volunteers

Project description:To study the difference of gene expression profile in minor salivary glands of female patients with primary Sjögren’s syndrome (pSS) and healthy volunteers

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Transcriptomic and Network Analysis of Minor Salivary Glands of Patients with Sjögren’s Syndrome

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The Transcriptome of Paired Major and Minor Salivary Gland Tissue in Patients With Primary Sjogren's Syndrome.

Project description: Not available

| S-EPMC8291032 | biostudies-literature

Hypomethylation mediates genetic association with the major histocompatibility complex genes in Sjögren's syndrome

Project description:A causal mediation analysis of DNA methylation as a mediator of nearby genetic association with Sjögren's syndrome using data collected from 131 female members of the Sjögren's International Collaborative Clinical Alliance registry, comprising of 64 Sjögren's syndrome cases and 67 non-cases.

2021-03-25 | GSE166373 | GEO

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