Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-sequencing data of intestinal tissue of pigs infected with parasites and adminstered proanthocyanidins (PAC)

ABSTRACT: RNA-sequencing data of intestinal tissue of pigs infected with parasites and adminstered proanthocyanidins (PAC)

PROVIDER: PRJNA728051 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

RNA-sequencing data of liver tissue of pigs infected with parasites and adminstered proanthocyanidins (PAC)

Project description:RNA-sequencing data of liver tissue of pigs infected with parasites and adminstered proanthocyanidins (PAC)

| PRJNA850179 | ENA

RNA-sequencing data of lung tissue of pigs infected with parasites and adminstered proanthocyanidins (PAC)

Project description:RNA-sequencing data of lung tissue of pigs infected with parasites and adminstered proanthocyanidins (PAC)

| PRJNA714131 | ENA

RNA-sequencing data of lung tissue of pigs infected with parasites and adminstered proanthocyanidins (PAC)

Project description:We show here the transcriptional response in the lung of pigs infected or not with Ascaris suum, fed either a control pr a PAC-enriched diet

2021-06-01 | GSE168840 | GEO

RNA-sequencing data of intestinal tissue of pigs infected with parasites and adminstered proanthocyanidins (PAC)

Project description:We show here the transcriptional response in the intestine of pigs infected or not with Ascaris suum, fed either a control pr a PAC-enriched diet

2021-05-08 | GSE174042 | GEO

RNA-sequencing data of liver tissue of pigs infected with parasites and adminstered proanthocyanidins (PAC)

Project description:We show here the transcriptional response in the liver of pigs infected or not with Ascaris suum, fed either a control pr a PAC-enriched diet

2022-06-20 | GSE206334 | GEO

RNA-sequencing data of intestinal tissue of mice adminstered proanthocyanidins (PAC)

Project description:RNA-sequencing data of intestinal tissue of mice adminstered proanthocyanidins (PAC)

| PRJNA706209 | ENA

RNA-sequencing data of intestinal tissue of mice adminstered proanthocyanidins (PAC)

Project description:We show here the transcriptional response in the distal small intestine of mice gavaged with two different PAC fractions

2021-03-04 | GSE168138 | GEO

RNA-sequencing data of intestinal tissue of mice adminstered proanthocyanidins (PAC) and infected with Trichuris muris (Tm)

Project description:RNA-sequencing data of intestinal tissue of mice adminstered proanthocyanidins (PAC) and infected with Trichuris muris (Tm)

| PRJNA735226 | ENA

RNA-sequencing data of intestinal tissue of mice adminstered proanthocyanidins (PAC) and infected with Trichuris muris (Tm)

Project description:We show here the transcriptional response in the caecum of mice infected with Tm with or without concurrent PAC administration

2022-01-01 | GSE176182 | GEO

Prebiotic proanthocyanidins inhibit bile reflux-induced esophageal adenocarcinoma through reshaping the gut microbiome

Project description:The gut and local esophageal microbiome progressively shift from healthy commensal bacteria to inflammatory-linked pathogenic bacteria in patients with gastroesophageal reflux disease, Barrett’s esophagus and esophageal adenocarcinoma (EAC). However, mechanisms by which microbial communities contribute to reflux-driven EAC remain incompletely understood and challenging to target. Herein, we utilized a rat reflux-induced EAC model to investigate targeting the gut microbiome-esophageal metabolome axis with cranberry proanthocyanidins (C-PAC) to inhibit EAC progression. Sprague Dawley rats, with or without reflux-induction received water or C-PAC ad libitum (700 µg/rat/day) for 25 or 40 weeks. C-PAC exerted prebiotic activity abrogating reflux-induced dysbiosis, and mitigating bile acid metabolism and transport, culminating in significant inhibition of EAC through TLR/NF-κB/TP53 signaling cascades. At the species level, C-PAC mitigated reflux-induced pathogenic bacteria (Streptococcus parasanguinis, Escherichia coli, and Proteus mirabilis). C-PAC specifically reversed reflux-induced bacterial, inflammatory and immune-implicated proteins and genes including Ccl4, Cd14, Crp, Cxcl1, Il6, Il1β, Lbp, Lcn2, Myd88, Nfkb1, Tlr2 and Tlr4 aligning with changes in human EAC progression, as confirmed through public databases. C-PAC is a safe promising dietary constituent that may be utilized alone or potentially as an adjuvant to current therapies to prevent EAC progression through ameliorating reflux-induced dysbiosis, inflammation and cellular damage.

2024-02-08 | GSE254633 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data