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Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes

ABSTRACT: Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes

PROVIDER: PRJNA728714 | ENA |

REPOSITORIES: ENA

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Transcriptomics analysis of enteroendocrine cells after vertical sleeve gastrectomy

Project description:We report here the transcriptome of sorted enteroendocrine cells from duodenum, ileum and colon from mice after vertical sleeve gastrectomy or sham operation, weight matched or not. We analyze the effect of region of origin and surgery and gene expression and found that only region of origin had an impact on EEC transcriptome

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Peptidomics profiling of the murine gut after vertical sleeve gastrectomy

Project description:Profiling of the murine peptidome along the gastrointestinal tract and pancreas in vertical sleeve gastrectomy and sham operated mice. The study compares the peptidome of various portions of the GI tract using intact mass spectrometry and database searching. These peptides included most gut hormones including proglucagon derived peptides, PYY, GIP, somatostatin, neurotensin amongst others.

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Gene expression profiling of the ileum following vertical sleeve gastrectomy compared to pair-fed sham surgery controls in mice with high-fat diet-induced obesity.

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Project description:Bariatric surgery, an effective treatment for obesity and diabetes, leads to profound remodeling of whole body energy homeostasis. We utilized a mouse model of vertical sleeve gastrectomy (VSG), a common bariatric surgery as a tool to identify novel secreted proteins and peptides that might act as important metabolic regulators. We analyzed gene expression in the stomach and intestines following VSG or sham surgery in diet-induced obese mice and sought to identify differentially regulated genes encoding secreted proteins/peptides.

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Gene expression profiling of the ileum following vertical sleeve gastrectomy compared to pair-fed sham surgery controls in mice with high-fat diet-induced obesity.

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Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes

Project description:This dataset consists of single-cell RNA-seq (10X) data of pancreatic islets isolated from healthy and diabetic db/db mice that underwent VSG surgery, Sham surgery (Control) and Sham surgery + pair-feeding (Calorie-restriction control).

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Transcriptomics analysis of enteroendocrine cells following vertical sleeve gastrectomy

Project description:Transcriptomics analysis of enteroendocrine cells following vertical sleeve gastrectomy

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Transcriptomics analysis of enteroendocrine cells after vertical sleeve gastrectomy

Project description:Transcriptomics analysis of enteroendocrine cells after vertical sleeve gastrectomy

| PRJNA497455 | ENA

Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes.

Project description: Not available

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Intestinal epithelial adaptations to vertical sleeve gastrectomy defined at single-cell resolution

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