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GeoMx Cancer Transcriptome Atlas (CTA) mRNA assay on 191 ROIs from a NSCLC tumor. [NSCLC_191_grid]

ABSTRACT: GeoMx Cancer Transcriptome Atlas (CTA) mRNA assay on 191 ROIs from a NSCLC tumor. [NSCLC_191_grid]

PROVIDER: PRJNA731460 | ENA |

REPOSITORIES: ENA

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GeoMx Cancer Transcriptome Atlas (CTA) mRNA assay on 191 ROIs from a NSCLC tumor.

Project description:GeoMx Cancer Transcriptome Atlas (CTA) mRNA assay on 191 ROIs from a NSCLC tumor.

| PRJNA731400 | ENA

GeoMx Cancer Transcriptome Atlas (CTA) mRNA assay

Project description:GeoMx Cancer Transcriptome Atlas (CTA) mRNA assay

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GeoMx Cancer Transcriptome Atlas (CTA) mRNA assay on 191 ROIs from a NSCLC tumor.

Project description:Dense spatial gene expression profiling of a NSCLC tumor. This study was part of Danaher & Kim et al., "Advances in mixed cell deconvolution enable quantification of cell types in spatially resolved gene expression data"

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GeoMx Cancer Transcriptome Atlas (CTA) mRNA assay on 191 ROIs from a NSCLC tumor. [NSCLC_191_grid]

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GeoMx Cancer Transcriptome Atlas (CTA) mRNA assay on an FFPE cell pellet array of mixed HEK293T and CCRF-CEM cell lines.

Project description:GeoMx Cancer Transcriptome Atlas (CTA) mRNA assay on an FFPE cell pellet array of mixed HEK293T and CCRF-CEM cell lines.

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GeoMx Cancer Transcriptome Atlas (CTA) mRNA assay

Project description:This SuperSeries is composed of the SubSeries listed below.

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GeoMX spatial transcriptomic on biphasic Malignant Pleural Mesothelioma

Project description:We applied a spatially resolved, high-dimensional transcriptomic approach to study MPM morpho-logical evolution. 139 regions across 8 biphasic MPMs (B-MPMs) were profiled using the GeoMx™Digital Spatial Profiler and Cancer Transcriptome Atlas to compare epithelioid and sarcomatoid components transcriptional profile and reconstruct the positional context of transcriptional activities and the spatial topology of MPM cells interactions.

2023-12-07 | E-MTAB-13043 | biostudies-arrayexpress

Genome-wide hsa-miR-191 target profile [chip]

Project description:Profile of transcripts isolated from Ago2 immunoprecipitation following transfection with miR-191 mature duplex and gene expression profile following transfection with miR-191 mature duplex

2015-03-01 | GSE63483 | GEO

Next Generation Sequencing (RNAseq) of non-small cell lung cancer

Project description:Cancer testis antigens (CTAs) are of clinical interest as biomarkers and present valuable targets for immunotherapy. To comprehensively characterize the CTA landscape of non-small cell lung cancer (NSCLC), we compared RNAseq data of 199 NSCLC tissues to the normal transcriptome of 142 samples from 32 different normal organs. Of 232 CTAs currently annotated in the CTdatabase, 96 were confirmed in NSCLC. To obtain an unbiased CTA profile of NSCLC, we applied stringent criteria on our RNAseq data set and defined 90 genes as CTAs, of which 55 genes were not annotated in the CTdatabase. Cluster analysis revealed that CTA expression is histology-dependent and concurrent expression is common. Immunohistochemistry confirmed tissue specific protein expression of selected genes. Furthermore, methylation was identified as a regulatory mechanism of CTA expression based on independent data from the Cancer Genome Atlas. The proposed prognostic impact of CTAs in lung cancer, was not confirmed, neither in our RNAseq-cohort nor in an independent meta-analysis of 1117 NSCLC cases.

2016-06-01 | GSE81089 | GEO

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