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PD-1-stimulated T cell subsets are transcriptionally and functionally distinct

ABSTRACT: PD-1-stimulated T cell subsets are transcriptionally and functionally distinct

PROVIDER: PRJNA731922 | ENA |

REPOSITORIES: ENA

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PD-1-stimulated T cell subsets are transcriptionally and functionally distinct

Project description:Analysis of 3 subsets of primary human CD4+ T cells (naive, CM, EM) stimulated with anti-CD3, anti-CD28 and PD-L1/PD-L2 for 18 hours. we show that naive, EM, and CM T cell subsets had distinct gene expression profiles following PD-1 ligation.

2021-07-01 | GSE174860 | GEO

PD-1-stimulated T cell subsets are transcriptionally and functionally distinct.

Project description: Not available

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Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets

Project description:Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets

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Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets I

Project description:Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets I

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Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets II

Project description:Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets II

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Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists

Project description:Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists

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A transcriptionally und functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small cell lung cancer treated with PD-1 blockade

Project description:Evidence from mouse chronic viral infection models suggests that CD8+ T cell subsets characterized by distinct expression levels of the receptor PD-1 diverge in their state of exhaustion and potential for reinvigoration by PD-1 blockade. However, it remains unknown whether T cells in human cancer adopt a similar spectrum of exhausted states based on PD-1 expression levels. We compared transcriptional, metabolic, and functional signatures of intratumoral CD8+ T lymphocyte populations with high (PD-1T), intermediate (PD-1N) and no PD-1 expression (PD-1-) from non-small cell lung cancer patients. We observed that, PD-1T T cells show a markedly different transcriptional and metabolic profile as compared to PD-1N and PD-1- lymphocytes, as well as an intrinsically high capacity for tumor recognition. Furthermore, while PD-1T lymphocytes are impaired in classical effector cytokine production, they produce CXCL13 that mediates immune cell recruitment to tertiary lymphoid structures. Strikingly, the presence of PD-1T cells was strongly predictive for both response and survival in a small cohort of non-small cell lung cancer patients treated with PD-1 blockade. The characterization of a distinct state of tumor-reactive, PD-1 bright lymphocytes in human cancer, which only partially resembles that seen in chronic infection, provides novel potential avenues for therapeutic intervention.

2018-05-22 | GSE99531 | GEO

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

Project description:Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

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Proteomics based analysis for associated PD-L1 in macrophage stimulated with extracellular adenosine signaling

Project description:We performed proteomics analysis to discover effector proteins for the post-transcriptional regulation of PD-L1 onhuman macrophages stimulated by adenosine signal.

2022-10-14 | PXD024512 | Pride

Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists [ExVivo]

Project description:Age-related alterations in immunity have been linked to increased incidence of infections and decreased responses to vaccines in the aging population. Human peripheral blood monocytes are known to promote antigen presentation and antiviral activities; however, the impact of aging on monocyte functions remains an open question. We present an in-depth global analysis examining the impact of aging on classical (CD14+CD16-), intermediate (CD14+CD16+), and non-classical (CD14dimCD16+) monocytes. Monocytes sorted from non-frail healthy adults (18-40 yrs) and old (≥ 65 yrs) individuals were analyzed after stimulation with TLR4, TLR7/8, and RIG-I agonists. Our data showed under non-stimulated conditions, monocyte subsets did not reveal significant age-related alternations; however, agonist stimulated-monocytes from adults and old subjects did show differences at the transcriptional and functional levels. These alternations in many immune-related transcripts and biological processes resulted in reduced production of IFNα, IFN, IL-1β, CCL20, and CCL8, and higher expression of CX3CR1 in monocytes from old subjects. Our findings represent a comprehensive analysis of the influence of human aging on pattern recognition receptors signaling and monocyte functions, and have implications for strategies to enhance the immune response in the context of infection and immunization.

2017-07-27 | GSE94497 | GEO

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