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Effect of chronic low dose of cadmium chloride exposure on long non-coding RNA expression in human bronchial epithelial BEAS-2B cells

ABSTRACT: Effect of chronic low dose of cadmium chloride exposure on long non-coding RNA expression in human bronchial epithelial BEAS-2B cells

PROVIDER: PRJNA732446 | ENA |

REPOSITORIES: ENA

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Effect of chronic low dose of cadmium chloride exposure on long non-coding RNA expression in human bronchial epithelial BEAS-2B cells

Project description:BEAS-2B cells were continuously exposed to 2.5 uM of cadmium chloride for 9 months and the expresssion of lncRNAs were analyzed by lncRNA microarray analysis.

2021-10-20 | GSE175472 | GEO

Human bronchial epithelial cell line Beas-2B

Project description:Human bronchial epithelial cell line Beas-2B were infected with Streptococcus pneumoniae at Multiplicity of Infection (MOI) of 0.5 and 1 or treated with lipoteichonic acid (LTA) for 9 and 16 h. The mRNA profile changes upon infection shall be determined to investigate Streptococci pathogenesis.

2023-02-01 | GSE195778 | GEO

Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

Project description:Time course transcriptomic profiling of human bronchial epithelial cell BEAS-2B exposed to a single dose of diesel and biomass ultrafine particles

2018-05-09 | E-MTAB-5157 | biostudies-arrayexpress

Integrative transcriptomic of human bronchial BEAS-2B exposed to seasonal urban PM

Project description:The aim of the present study was to characterize a common and unique signalling pathways associated to two seasonal particulate matter (PM) (winter PM2.5 and summer PM10) in human bronchial BEAS-2B cells by mean of a global transcriptomic profiling (including genes and miRNA) and the investigation of selected pathways at protein level.

2016-05-26 | E-MTAB-3630 | biostudies-arrayexpress

high-throughput sequencing of circRNAs in T-BEAS-2B cells and C-BEAS-2B cells

Project description:We report the differential expression of circRNAs between T-BEAS-2B cells (cadmium-transformed BEAS-2B cells) and C-BEAS-2B cells (passage-matched control BEAS-2B cells) by high-throughput sequencing. T-BEAS-2B cells are BEAS-2B cells transformed by cadmium at 2.0 μM for twenty weeks, and C-BEAS-2B cells are their passage-matched control. RNAs were sequenced on Illumina HiSeq Xten platform in triplicates, and expressions of circRNAs were calculated by TPM (transcripts per kilobase of exon model per million mapped reads). Clean data per sample exceeds 10 GB. We find 235 significantly up-regulated circRNAs and 271 significantly down-regulated circRNAs in T-BEAS-2B cells relative to C-BEAS-2B cells. Our work provides clues and evidence for exploring the mechanism of circRNAs in cadmium carcinogenesis.

2024-01-26 | GSE165549 | GEO

Human bronchial cells (BEAS-2B) treated with amiodarone (AM)

2011-01-10 | GSE20582 | GEO

Integrative transcriptomic profiling of human bronchial BEAS-2B exposed to seasonal urban PM

2016-05-26 | E-MTAB-3629 | biostudies-arrayexpress

Expression data from BEAS-2B cells

Project description:BEAS-2B cells are human bronchial epithelial cells, and often used as a in vitro model for the detection of potential pulmonary toxicity of chemicals. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes after treated with chemical substance

2017-01-10 | GSE93329 | GEO

Expression data from BEAS-2B cells II

2019-03-07 | GSE127962 | GEO

Human bronchial cells (BEAS-2B) treated with amiodarone (AM)

Project description:AAmiodarone is an antiarrhythmic drug and representatively induce pulmonary phospholipidosis. Amiodarone-induced toxicity has been a serious unpredictable side effect of the treatment and an important clinical problem. Possible causes include allergic, cytotoxic or immunologic reactions to this agent. We examined the consequences of the mechanism of amiodarone-induced pulmonary toxicity gene expression in BEAS-2B cells, huma bronchial cell line, by microarray. The expression of these genes are potential biomarker of amiodarone-induced pulmonary toxicity. Also, We provide a clue about mechanism of pulmonary toxic action by these clinical chemotherapeutic agents. BEAS-2B cells were seeded and after incubation for 24 h at 37C, the cells were treated with 29.388 μM(IC20) amiodarone for 48 h. And after total RNA isolation, gene expression analysis was conducted using a 44-k whole human genome microarray. Labeling and hybridization were performed using a FairPlay microarray labeling kit, followed by the coupling of Cy3 (controls) or Cy5 (treated samples) dye. The hybridized slides were scanned using a GenePix 4000B microarray scanner, and the images were analyzed using GenePix 4.1 software to obtain gene expression ratios. The fluorescence intensity of each spot was calculated by local median background subtraction. We then used the robust scatter-plot smoother LOWESS function to perform intensity-dependent normalization of gene expression. Scatter-plot analysis was performed using Microsoft Excel 2000. A significance analysis of microarray (SAM) was performed for genes with significant changes in expression.

2011-01-10 | E-GEOD-20582 | biostudies-arrayexpress

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