Project description:MACC1 is a decisive driver of metastasis. In this data set the expression changes of shRNA mediated knock down is analyzed. We used microarrays to detail the global programme of gene expression changing upon MACC1 knock down.
Project description:To reveal the difference in mRNA expression profile between non-senescent cancer cells and senescent cancer cells in colorectal cancer, CRC cell line SW620 was treated with hydrogen peroxide to induce senescent.
Project description:The purpose of this study is to identify the disregulated mRNAs after knockdown of UICLM (up-regulated in colorectal cancer liver metastasis, accession number: NR_033841) in SW620 cells. A total of 188 mRNAs were identified to be differentially expressed after knockdown of UICLM in SW620 cells
Project description:We found GAP43 was significantly downregulated in colorectal cancer. So we reintroduced GAP43 to colorectal cancer cell line, and investigated the influence to cancer cells. In order to get the transcriptome-wide impact of GAP43 overexpression in colorectal cancer, we made stable transfected GAP43 in SW620 cancer cells, and mRNA-seq were performed (Sequenced with PE150, and 20M reads were generated.) This study provides the DEGs of GAP43 overexpressed and control colorectal cancer cells.
Project description:Adenocarcinoma cell line SW620 were treated with tetradecylthioacetic acid,TTA, or control (NaOH) for 24 h. degrees RNA isolated, Affymetrix gene expression