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Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional

ABSTRACT: Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional

PROVIDER: PRJNA734567 | ENA |

REPOSITORIES: ENA

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Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional

Project description:To identify genes regulating the jamming transition in healthy distal airway epithelia compared to the dysregulated state in idiopathic pulmonary fibrosis epithelia (IPF) we analyzed RNA from three (3) healthy and four (4) IPF patient cells grown at air-liquid-interface (ALI). This bulk analysis of 3 timepointes (days 4, 8, and 14 of ALI) spanning the jamming transition revealed an enrichment for ERBB- and YAP-related genes.

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Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional.

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Expression data from human airway epithelia exposed to IL13

Project description:IL13 exposure results in a distinct gene expression profile in human airway epithelia. We investigated whether this expression profile can be used to identify compounds able to block goblet cell metaplasia We used microarrays to determine transcriptional changes in cultures of primary human airway epithelia grown at the air-liquid interface after exposure to 20 ng/mL recombinant human IL13

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