Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparative transcriptome analysis reveals different adaptation mechanisms for degradation of very-long chain and normal-long chain alkanes in Dietzia sp. DQ12-45-1b

ABSTRACT: Comparative transcriptome analysis reveals different adaptation mechanisms for degradation of very-long chain and normal-long chain alkanes in Dietzia sp. DQ12-45-1b

PROVIDER: PRJNA734595 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Comparative transcriptome analysis reveals different adaptation mechanisms for degradation of very-long chain and normal-long chain alkanes in Dietzia sp. DQ12-45-1b

Project description:In this study we compare the transcriptome of the strain Dietzia sp. DQ12-45-1b grown in octacosane , hexadecane and glucose for the characterization distinct adaption mechanisms under different alkane substrates

2021-09-14 | GSE176019 | GEO

Differential Protein Expression During Growth on Medium Versus Long-Chain Alkanes in the Obligate Marine Hydrocarbon-Degrading Bacterium Thalassolituus oleivorans MIL-1

Project description:The marine obligate hydrocarbonoclastic bacterium Thalassolituus oleivorans MIL-1 metabolises a broad range of aliphatic hydrocarbons almost exclusively as carbon and energy sources. We used LC-MS/MS shotgun proteomics to identify proteins involved in aerobic alkane degradation during growth on medium- (n-C14) or long-chain (n-C28) alkanes.

2019-01-14 | PXD011824 | Pride

Critical role for very-long chain sphingolipids in invariant natural killer T cell development and homeostasis

Project description:The role of sphingolipids (SLs) in the immune system has come under increasing scrutiny recently due to the emerging contributions that these important membrane components play in regulating a variety of immunological processes. The acyl chain length of SLs appears particularly critical in determining SL function. Here we show a role for very-long acyl chain SLs (VLC-SLs) in invariant natural killer T (iNKT) cell maturation in the thymus and homeostasis in the liver. Ceramide synthase 2 (CerS2) null mice, which lack VLC-SLs, were susceptible to a hepatotropic strain of lymphocytic choriomeningitis virus, which is due to a reduction in the number of iNKT cells. Bone marrow chimera experiments indicated that hematopoietic-derived VLC-SLs are essential for maturation of iNKT cells in the thymus, whereas parenchymal-derived VLC-SLs are crucial for iNKT cell survival and maintenance in the liver. Our findings suggest a critical role for VLC-SL in iNKT cell physiology.

2017-10-15 | GSE104205 | GEO

Critical role for very-long chain sphingolipids in invariant natural killer T cell development and homeostasis

Project description:Critical role for very-long chain sphingolipids in invariant natural killer T cell development and homeostasis

| PRJNA412033 | ENA

Quantitative proteomics characterization of proteins modified by very long chain fatty acids (VLCFAs) under necroptosis

Project description:Necroptosis is a caspase-independent form of regulated cell death that is characterized by membrane permeabilization and rupture. This membrane rupture is responsible for the inflammatory properties of necroptosis and is critical for disease states involving this process. In efforts to understand how lipids might contribute to necroptosis, we previously showed that saturated very long chain fatty acids (VLCFAs) are functionally involved in this process, potentially through protein fatty acylation. Here we define the scope of protein acylation by saturated VLCFAs during necroptosis using a clickable lipid analog and IonStar quantitative proteomics.As a result, a total of 1672 proteins were quantified with high precision and no missing data across samples in the same condition. 1267 were detected with higher abundances in control cells and 405 were detected with higher abundance in necroptotic conditions.

2021-05-25 | PXD022527 | Pride

Dietzia sp. DQ12-45-1b

Project description:Dietzia sp. DQ12-45-1b Genome sequencing

| PRJNA588652 | ENA

Unsaturation of very-long-chain ceramides regulates hypoxia response by modulating ethylene signaling in Arabidopsis

Project description:Lipid remodeling is crucial for hypoxic tolerance in animals, whilst little is known about the hypoxia-induced lipid dynamics in plant cells. Here we performed a mass spectrometry-based analysis to survey the lipid profiles of Arabidopsis rosettes under various hypoxic conditions. We observed that hypoxia caused a significant increase in total amounts of phosphatidylserine, phosphatidic acid and oxylipins, but a decrease in phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Particularly, significant gains in the polyunsaturated species of PC, PE and phosphatidylinositol, and losses in their saturated and mono-unsaturated species were evident during hypoxia. Moreover, hypoxia led to a remarkable elevation of ceramides and hydroxyceramides. Depletion of ceramide synthases LOH1, LOH2, and LOH3 enhanced plant sensitivity to dark submergence (DS), but displayed more resistance to submergence under light than wild type. Consistently, levels of unsaturated ceramide species (22:1, 24:1, and 26:1) predominantly declined in the loh1, loh2, and loh3 mutants under DS. Evidence that C24:1-ceramide interacted with recombinant CTR1 protein in vitro, enhanced ER-to-nucleus translocation of EIN2-GFP and stabilization of EIN3-GFP in vivo, suggests a role of ceramides in modulating ethylene signaling. The DS-sensitive phenotypes of loh mutants were rescued by a ctr1-1 mutation. Thus, our findings demonstrate that unsaturation of very-long-chain ceramides is a protective strategy for hypoxic tolerance in Arabidopsis. Arabidopsis Affymetrix GeneChip arrays were probed with RNAs isolated from leaves of untreated plants (controls) and plants upon hypoxia under light submergence for 48 h.

2016-07-24 | E-GEOD-59719 | biostudies-arrayexpress

Dietzia sp. DQ12-45-1b

Project description:Dietzia sp. DQ12-45-1b mDNA Raw sequence reads

| PRJNA627364 | ENA

Project description:long-chain n-alkanes-degrading culture

| PRJNA545407 | ENA

Unsaturation of very-long-chain ceramides regulates hypoxia response by modulating ethylene signaling in Arabidopsis

2016-07-24 | GSE59719 | GEO