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Maternal Circulating Exosomal miRNAs as Non-Invasive Biomarkers for Prediction of Fetal Ventricular Septal Defect

ABSTRACT: Maternal Circulating Exosomal miRNAs as Non-Invasive Biomarkers for Prediction of Fetal Ventricular Septal Defect

PROVIDER: PRJNA735086 | ENA |

REPOSITORIES: ENA

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Maternal Circulating Exosomal miRNAs as Non-Invasive Biomarkers for Prediction of Fetal Ventricular Septal Defect

Project description:Objective:This study aims to discover circulating exosomal miRNAs as potential noninvasive biomarkers early detection of fetus with ventricular septal defect (VSD). Method:A total of 182 pregnant women including 91 VSD cases and 91 matched controls were included in this study. Exosomes were isolated and next-generation sequencing was used to obtain a profile of dysregulated exosomal miRNA. The differential abundance was verified by quantitative real-time PCR (q RT-PCR). . Receiver operating characteristic (ROC) curves were conducted to evaluate the diagnostic accucary Results: 77 serum exosomal miRNA were uncovered to be differentially expressed in the VSD group as compared to the control group. Among these, five down-regulated exosomal miRNA were validated by qRT-PCR. hsa-miR-146a-5p was identified to be capable of distinguishing VSDs from controls (area under the ROC (AUC): 0.997; p < 2.2e-16). Conclusion: circulating exosomal miRNA, in particular, hsa-miR-146a-5pmay be a predictive biomarker for non-invasive prenatal diagnosis of fetal VSDs.

2021-06-05 | GSE176134 | GEO

Analysis of Amniotic Fluid-derived lncRNAs and mRNAs in Fetuses with ventricular septal defect

Project description:Ventricular septal defect (VSD) is one of the most prevalent birth defects. The pathogenesis of VSD remains unknown. to analyze the expression of AF-derived lncRNAs and their roles in VSD development, Arraystar Human LncRNA Microarray V5.0 is employed for the global profiling of human lncRNAs and protein-coding transcripts.

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Circulating MicroRNA: Myocardium-Derived Prenatal Biomarker of Ventricular Septal Defects

Project description:MicroRNAs (miRNAs) regulate transcription factors and relate to ventricular septal defect (VSD) occurrence, progression and outcome. Recently, circulating miRNAs from maternal blood and amniotic fluid have been used as biomarkers for congenital heart defect (CHD) diagnosis. However, whether circulating miRNAs are associated with foetal heart tissue remains unknown. Dimethadione (DMO) induced a VSD rat model and the miRNA expression profiles of the myocardium, amniotic fluid and maternal serum were analysed. MiRNAs were differentially expressed in the myocardium, amniotic fluid or maternal serum of VSD foetal rats and might be involved in cardiomyocyte differentiation and apoptosis.

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Analysis of Amniotic Fluid-derived lncRNAs and mRNAs in Fetuses with ventricular septal defect

Project description:Analysis of Amniotic Fluid-derived lncRNAs and mRNAs in Fetuses with ventricular septal defect

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Maternal Circulating Exosomal miRNAs as Non-invasive Biomarkers for the Prediction of Fetal Ventricular Septal Defect.

Project description: Not available

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Transcription profiling of human right ventricular samples acquired during cardiac surgery

Project description:Right ventricular samples were serially acquired during surgical repair of ventricular septal defect. Expression profiling revealed three patterns of gene expression: (1) increased expression above control levels within one hour of cardioplegic arrest, with further amplification during early reperfusion; (2) increased expression limited to the reperfusion phase; and (3) reduced expression during reperfusion. Experiment Overall Design: 4 replicates each: Experiment Overall Design: Stage2, End-ischemia Experiment Overall Design: Stage1, Immediately post-cardioplegic arrest Experiment Overall Design: Stage3, After 5 min. Reperfusion

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Circulating MicroRNA: Myocardium-Derived Prenatal Biomarker of Ventricular Septal Defects

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Molecular Signatures of cardiac defects in Down syndrome lymphoblastoid cell lines (congenital heart disease)

2012-08-15 | GSE34457 | GEO

Molecular Signatures of cardiac defects in Down syndrome lymphoblastoid cell lines (congenital heart disease)

Project description:Molecular Signatures of cardiac defects in Down syndrome lymphoblastoid cell lines. In this study, we want to identify genes and pathways specifically dysregulated in atrioventricular septal defect and /or atrial septal defect + ventricular septal defect in case of trisomy 21. Total RNA obtained from DS lymphoblastoid cell lines without congenital heart disease compared to cell lines from DS with congenital heart disease.

2012-08-14 | E-GEOD-34457 | biostudies-arrayexpress

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